assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mM
storage temp.
2-8°C
SMILES string
N21[C@H](C[C@H]5[C@@H](C2)C[C@H]([C@@H]([C@H]5C(=O)OC)OC)OC(=O)c6cc(c(c(c6)OC)OC)OC)c3[nH]c4c(c3CC1)ccc(c4)OC
InChI
1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChI key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
General description
Binds the vesicular monoamine transporter (VMAT2) and acts as an irreversible transport inhibitor of biogenic amines. Used as a long-lasting bioamine depleter. Prevents bioamine transport into synaptic vesicles and chromaffin granules. Used as antihypertensive and antipsychotic drugs.
Biochem/physiol Actions
Primary Target
VMAT2
VMAT2
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Oe, T., et al. 2010. Neurosci.169, 1860.
Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39.
Heslop, E., et al. 1999. Neuropharmacol.38, 883.
Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.
Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39.
Heslop, E., et al. 1999. Neuropharmacol.38, 883.
Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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注意喚起語
Danger
ハザードコード
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
標的臓器
Central nervous system
一体何が起きているの?
WGK 3
引火点 (F)
Not applicable
引火点(°C)
Not applicable
保管分類
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

