5.09272
Hydroxychloroquine Sulfate
≥98% (HPLC), primaquine analog, powder
別名:
Hydroxychloroquine Sulfate, HCQ, Autophagy Inhibitor
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この商品について
実験式（ヒル表記法）:
C18H28ClN3O5S
CAS番号:
分子量:
433.95
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160702
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
製品名
Hydroxychloroquine Sulfate,
assay
≥98% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 100 mg/mL
storage temp.
2-8°C
SMILES string
CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
InChI key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
General description
A cell-permeable, orally available quinoline derivative with anti-malarial properties. Increases intralysosomal pH and thereby impairs autophagic degradation process. Reduces metabolic activity and suppresses proliferation of human dermal fibroblasts (IC50 = 30 µM). Shown to inhibit ERK1/2 phosphorylation (Thr202/Try204), but does not affect Akt and mTOR phosphorylation. Shown to directly block the binding of CXCL12 to CXCR4 and inhibit downstream effects in pancreatic cancer cells (EC50 = 9.8 µM). Effectively antagonizes CXCR4-mediated cell proliferation in PANC-1, Hs-766T, and MIAPaCa-2 cells. Suppresses Toll-like receptor 9 (TLR-9)-mediated dendritic cell activation and displays anti-inflammatory properties.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kim, J., et al. 2012. PLoS ONE.7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol.129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol.22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol.129, 2333.
Kuznik, A., et al. 2011. J. Immunol.186, 4794.
Ramser, B., et al. 2009. J. Invest. Dermatol.129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol.22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol.129, 2333.
Kuznik, A., et al. 2011. J. Immunol.186, 4794.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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注意喚起語
Warning
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
保管分類
11 - Combustible Solids
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable