551850
キナクリン 二塩酸塩
A non-specific phospholipase A2 (PLA2) inhibitor.
別名:
6-クロロ-9-(4-ジエチルアミノ-1-メチルブチルアミノ)-2-メトキシアクリジン 二塩酸塩, アテブリン 二塩酸塩, メパクリン 二塩酸塩
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この商品について
実験式（ヒル表記法）:
C23H30ClN3O · 2HCl
CAS番号:
分子量:
472.88
NACRES:
NA.77
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
4834013
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
description
Merck USA index - 14, 8044
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
water: soluble
shipped in
ambient
storage temp.
10-30°C
SMILES string
Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChI key
UDKVBVICMUEIKS-UHFFFAOYSA-N
General description
A non-specific phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamine oxidase (MAO).
Biochem/physiol Actions
非選択的MAO-A/Bインヒビタ-です。
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 4.4 µM in suppressing glibenclamide-sensitive K+-currents
Preparation Note
Stock solutions are stable for up to 60 h at 20°C.
Other Notes
Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther.262, 1161.
Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev.21, 33.
Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 714.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther.262, 1161.
Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev.21, 33.
Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 714.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3