557324
Riluzole
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
別名:
Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
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この商品について
実験式（ヒル表記法）:
C8H5F3N2OS
CAS番号:
分子量:
234.20
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
description
Merck USA index - 14, 8223
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
HCl: 0.1 N, DMSO: 40 mg/mL
cation traces
heavy metals: ≤20 ppm
shipped in
ambient
storage temp.
2-8°C
SMILES string
FC(F)(F)Oc1cc2[s]c(nc2cc1)N
InChI
1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChI key
FTALBRSUTCGOEG-UHFFFAOYSA-N
General description
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Inhibits glutamate release and blocks Na+ channels
Inhibits glutamate release and blocks Na+ channels
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
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注意喚起語
Danger
ハザードコード
Hazard Classifications
Acute Tox. 2 Oral
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3