557450
Ruthenium Red
Calcium channel blocker, solid
å¥å:
Ruthenium Red, Ammoniated Ruthenium Oxychloride, RR
ãã°ã€ã³ã§çµç¹ã»å¥çŽäŸ¡æ Œãã芧ãã ããã
ãµã€ãºãéžæããŠãã ãã
衚瀺ãå€æŽãã
ãã®ååã«ã€ããŠ
ååŠåŒ:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
CASçªå·:
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Form:
solid
Storage condition:
OK to freeze, desiccated
ãã¯ãã«ã«ãµãŒãã¹
ãå°ãã®ããšãããã°ãçµéšè±å¯ãªãã¯ãã«ã«ãµãŒãã¹ããŒã ãã客æ§ããµããŒãããŸãã
ãæäŒãããŸã補åå
Ruthenium Red, A blocker of transmembrane Ca2+ fluxes (IC50 = 7 µM) that attenuates capsaicin-induced cation channel opening.
Quality Segment
description
Merck USA index - 14, 8300
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
red-black
solubility
ammonia: soluble, water: soluble
shipped in
ambient
storage temp.
10-30°C
General description
A blocker of transmembrane Ca2+ fluxes (IC50 = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Inhibits K+-stimulated catecholamine secretion (IC50 = 6 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Blocker of transmembrane Ca2+ fluxes
Blocker of transmembrane Ca2+ fluxes
Product does not compete with ATP.
Reversible: no
Target IC50: 7 µM in blocking transmembrane Ca2+ fluxes; 6 µM inhibiting K+-stimulated catecholamine secretion
Other Notes
Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
泚æåèµ·èª
Warning
ãã¶ãŒãã³ãŒã
泚æäºé
Hazard Classifications
Acute Tox. 4 Oral
ä¿ç®¡åé¡
11 - Combustible Solids
WGK
WGK 2
åŒç«ç¹ (F)
Not applicable
åŒç«ç¹ïŒÂ°CïŒ
Not applicable
ææ°ããŒãžã§ã³ã®ãããããéžæããŠãã ããïŒ
以åãã®è£œåãè³Œå ¥ããã ããããšãããå Žå
ææžã©ã€ãã©ãªã§ãæè¿è³Œå ¥ãã補åã®ææžãæ€çŽ¢ã§ããŸãã