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574776

Swinholide A, Theonella swinhoei

Name: Swinholide A, <i>Theonella swinhoei</i>
Brand: MM

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro.

別名:

Swinholide A, Theonella swinhoei

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この商品について

実験式（ヒル表記法）:

C₇₈H₁₃₂O₂₀

CAS番号:

95927-67-6

分子量:

1389.87

MDL number:

MFCD01861928

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

oil

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

assay

≥98% (HPLC)

form

oil

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

colorless

solubility

acetone: soluble, ethanol: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

O1[C@H](C[C@@H](C[C@@H]1C)OC)CC[C@@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C=C\C(=C\C[C@@H](C[C@H]3O[C@H](C[C@@H]([C@H]([C@H](C[C@H]([C@@H]([C@H](OC(=O)\C=C\C(=C\C[C@@H](C[C@H]5O[C@H](C[C@@H]([C@H]([C@H](C[C@H]([C@@H]2C)O)O)C)OC)CC=C5)O)\C)[C@H]([C@@H](O)[C@H](CC[

InChI

1S/C78H132O20/c1-45-23-29-57(79)37-59-19-17-21-61(95-59)41-71(91-15)52(8)68(82)44-70(84)54(10)78(56(12)76(88)48(4)28-32-64-40-66(90-14)36-50(6)94-64)98-74(86)34-26-46(2)24-30-58(80)38-60-20-18-22-62(96-60)42-72(92-16)51(7)67(81)43-69(83)53(9)77(97-73(85)3

InChI key

RJVBVECTCMRNFG-ANKJNSLFSA-N

詳細

General description

A dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Disrupts the actin cytoskeleton

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

ハザードコード

H413

注意事項

P273 - P501

Hazard Classifications

Aquatic Chronic 4

保管分類

10 - Combustible liquids

引火点 (F)

Not applicable

引火点（°C）