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645900

Triptolide

Name: Triptolide
Brand: MM

from Tripterygium wilfordii, ≥95% (HPLC), DEVD-cleaving caspases activator, solid

別名:

Triptolide, Tripterygium wilfordii, PG490

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この商品について

実験式（ヒル表記法）:

C₂₀H₂₄O₆

CAS番号:

38748-32-2

分子量:

360.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00210565

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

製品名

Triptolide, Tripterygium wilfordii, A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

Quality Segment

100

description

RTECS - YK7751000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O1[C@@]32[C@]5(O[C@H]5C[C@@H]6[C@@]3(CCC7=C6COC7=O)C)[C@@H]([C@]4(O[C@H]4[C@@H]21)C(C)C)O

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-CIVMWXNOSA-N

詳細

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H330,H361f

pcodes

P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

保管分類

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c