MAB4423
Anti-SOX-2 Antibody, clone 10H9.1
clone 10H9.1, from mouse
別名:
ANOP3, MCOPS3, MGC2413
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
10H9.1, monoclonal
Species reactivity:
human, mouse
Application:
ICC, WB
Citations:
17
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10H9.1, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
mouse ... Sox2(20674)
General description
SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
~34 kDa observed
Immunogen
Recombinant protein corresponding to human SOX-2.
Application
Anti-SOX-2 Antibody, clone 10H9.1 detects level of SOX-2 & has been published & validated for use in WB & IC.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation
Neural Stem Cells
Pluripotent & Early Differentiation
Neural Stem Cells
Western Blot Analysis: 1.0 µg/mL from a representative lot detected SOX-2 in H9 human stem cell lysate.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected SOX-2 in human RenCX cells.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected SOX-2 in human RenCX cells.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse embryonic stem cells
Mouse embryonic stem cells
Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected SOX-2 in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected SOX-2 in mouse embryonic stem cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
MAB4423:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Aleksandra Beylina et al.
Stem cell research, 53, 102354-102354 (2021-06-06)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with inherited forms of Parkinson's disease (PD), causing disease by a gain of kinase function. Here, we describe a series of isogenic iPSC lines with any of five pathogenic mutations (N1437H
Ana Joana Duarte et al.
Stem cell research, 45, 101794-101794 (2020-05-11)
Fabry Disease (FD) is a multisystemic X-linked disorder that belongs to the group of lysosomal storage disorders (LSDs). Causal mutations on alpha-galactosidase A (α-Gal A) commonly lead to abnormal protein and consequently to FD. Since it is an X-linked disease
Jianghong Man et al.
Cell stem cell, 22(1), 104-118 (2017-12-05)
Tumor hypoxia is associated with poor patient survival and is a characteristic of glioblastoma. Notch signaling is implicated in maintaining glioma stem-like cells (GSCs) within the hypoxic niche, although the molecular mechanisms linking hypoxia to Notch activation have not been
Lanjuan Mi et al.
Frontiers in oncology, 11, 751792-751792 (2021-12-07)
Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor. Ribosome biogenesis is an essential cellular process to maintain cell growth, but its
Alexis Rugamba et al.
Cells, 10(7) (2021-07-03)
Recently, natural compounds have been used globally for cancer treatment studies. Silibinin is a natural compound extracted from Silybum marianum (milk thistle), which has been suggested as an anticancer drug through various studies. Studies on its activity in various cancers
資料
Human iPSC neural differentiation media and protocols used to generate neural stem cells, neurons and glial cell types.
Fibroblast growth factors (FGFs) regulate developmental pathways and mesoderm/ectoderm patterning in early embryonic development.
プロトコル
A stem cell culture protocol to generate 3D NSC models of Alzheimer’s disease using ReNcell human neural stem cell lines.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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