MABC121
Anti-ALDH3A1, clone 10C7.1 Antibody
clone 10C7.1, from mouse
別名:
Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
10C7.1, monoclonal
Species reactivity:
human
Application:
IHC, WB
Citations:
1
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
10C7.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ALDH3A1(218)
General description
Aldehyde dehydrogenase family 3 member A1 (ALDH3A1 or Aldh3A1) is a member of the aldehyde dehydrogenase (ALDH) superfamily. The ALDH family is a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. ALDHs are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. They are suggested to play a major role in the detoxification of alcohol-derived acetaldehyde. ALDH3A1 is shown to oxidize preferentially aromatic aldehyde substrates, and it may play a role in the oxidation of toxic aldehydes. ALDH3A1 is highly expressed in stomach, esophagus, lung, and cornea. It represents between 5 to 50% of the water soluble protein fraction in mammalian corneas and it is implied to protect the cornea from UV-induced oxidative stress.
~50 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
Immunogen
GST-tagged recombinant protein corresponding to the N-terminus of human ALDH3A1.
Application
Detect Aldehyde Dehydrogenase using this mouse monoclonal antibody, Anti-ALDH3A1, clone 10C7.1 Antibody validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ALDH3A1 in human stomach and lung tissues.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in A549 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected ALDH3A1 in 10 µg of A549 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected ALDH3A1 in 10 µg of A549 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
MABC121:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Erika Terzuoli et al.
Cancers, 11(12) (2019-12-11)
Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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