A1221
AH6809
≥98%, crystalline solid or supercooled liquid
別名:
6-イソプロポキシ-9-オキソキサンテン-2-カルボン酸
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この商品について
実験式（ヒル表記法）:
C17H14O5
CAS番号:
分子量:
298.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
AH6809, ≥98%, crystalline solid or supercooled liquid
InChI key
AQFFXPQJLZFABJ-UHFFFAOYSA-N
SMILES string
CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1
InChI
1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
assay
≥98%
form
crystalline solid or supercooled liquid
solubility
ethanol: soluble 2.5 mg/mL
DMSO or DMF: soluble 8 mg/mL
Quality Level
Biochem/physiol Actions
DP/EPプロスタノイドレセプタ-のアンタゴニストであり、DPレセプタ-に対する高い親和性を有していますが、マウスのEP1, EP2プロスタノイドレセプタ-にも弱いアンタゴニストとして作用します。
AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.
Application
AH6809 has been used:
- as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
- as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
- as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)
Features and Benefits
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
A1221-5MG-PW: + A1221-BULK: + A1221-VAR: + A1221-25MG: + A1221-5MG:
jan
F Stanisçuaski et al.
Journal of insect physiology, 56(9), 1078-1086 (2010-03-13)
Urease isoforms from jack bean seeds are toxic to insects, and this entomotoxic effect is mostly due to the release of a peptide by insect digestive enzymes. We previously demonstrated that jack bean urease (JBU) has antidiuretic effects on Rhodnius
Sarah A Maher et al.
American journal of respiratory and critical care medicine, 180(10), 923-928 (2009-09-05)
A significant population of patients with severe asthma and chronic obstructive pulmonary disease is less responsive to beta(2)-adrenoceptor agonists and corticosteroids, and there are possible safety issues concerning long-term use of these drugs. Inhaled prostaglandin E(2) (PGE(2)) is antiinflammatory and
Hiroyuki Isshiki et al.
Biochemical and biophysical research communications, 489(3), 305-311 (2017-06-01)
Methods for the artificial three-dimensional (3D) culture of mouse and human small-intestinal and large-intestinal stem cells have been established with CD24 Using various tissue homogenates, we investigated the colonic organoid forming capacity under the TMDU protocol immediately adjacent to Ootani's
Marchessini Casibang et al.
Lung cancer (Amsterdam, Netherlands), 36(1), 33-42 (2002-03-14)
The effects of prostaglandin (PG)E2 on lung cancer cells were investigated. 3H-PGE2 bound with high affinity to membranes derived from small cell lung cancer (SCLC) and non-SCLC (NSCLC) cell lines. Using NSCLC NCI-H1299 membranes, specific 3H-PGE2 binding to NCI-H1299 membranes
Shalini Jain et al.
Cancer research, 68(19), 7750-7759 (2008-10-03)
In cancer management, the cyclooxygenase (COX)-targeted approach has shown great promise in anticancer therapeutics. However, the use of COX-2 inhibitors has side effects and health hazards; thus, targeting its major metabolite prostaglandin E(2) (PGE(2))-mediated signaling pathway might be a rational
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