A1757
6-アザウラシル
≥98%, powder
別名:
1,2,4-トリアジン-3,5(2H,4H)-ジオン, 3,5-ジヒドロキシ-1,2,4-トリアジン, 6-アザ-2,4-ジヒドロキシピリミジン
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この商品について
実験式（ヒル表記法）:
C3H3N3O2
CAS番号:
分子量:
113.07
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-318-0
MDL number:
Beilstein/REAXYS Number:
116472
Assay:
≥98%
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
Application
6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability. It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.
Biochem/physiol Actions
6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
A1757-1G: + A1757-100G: + A1757-5G: + A1757-25G: + A1757-250MG: + A1757-VAR: + A1757-BULK:
jan
Kostyantyn V Dmytruk et al.
Metabolic engineering, 13(1), 82-88 (2010-11-03)
Currently, the mutant of the flavinogenic yeast Candida famata dep8 isolated by classic mutagenesis and selection is used for industrial riboflavin production. Here we report on construction of a riboflavin overproducing strain of C. famata using a combination of random
Valérie Declerck et al.
The Journal of organic chemistry, 76(2), 708-711 (2010-12-25)
A short and efficient synthesis of the previously unknown N-aminoazetidinecarboxylic acid has been established using a photochemical [2 + 2] cycloaddition strategy starting from 6-azauracil. Chiral derivatization with a nonracemic oxazolidinone provided access to both enantiomers of the title product.
Sittinan Chanarat et al.
Genes & development, 25(11), 1147-1158 (2011-05-18)
Different steps in gene expression are intimately linked. In Saccharomyces cerevisiae, the conserved TREX complex couples transcription to nuclear messenger RNA (mRNA) export. However, it is unknown how TREX is recruited to actively transcribed genes. Here, we show that the
methods in molecular biology
steroid receptor methods (2001)
Mihajlo Etinski et al.
Physical chemistry chemical physics : PCCP, 12(48), 15665-15671 (2010-08-04)
The photophysical properties of 6-azauracil were studied by means of ab initio quantum chemical methods. On the basis of our calculations we propose here the following mechanism for the lack of fluorescence and the high triplet quantum yield that was
関連コンテンツ
Product Information Sheet
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