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Merck

A5106

抗ABI1 ウサギ宿主抗体

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

抗Abelson interactor 1抗体, 抗Abl-interactor protein 1抗体, 抗Nap1結合タンパク質NAP1BP抗体, 抗eps8結合タンパク質抗体, 抗スペクトリンSH3ドメイン結合タンパク質1 SSH3BP1抗体, 抗相互作用因子タンパク質AblBP4抗体

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この商品について

NACRES:
NA.41
UNSPSC Code:
12352203

主要文書

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製品名

抗ABI1 ウサギ宿主抗体, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~65 kDa

species reactivity

human, canine (predicted), mouse (predicted), rat

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.5-1.0 μg/mL using A431 cell lysate
western blot: 0.5-1.0 μg/mL using extract of rat brain cytosolic fraction (S1)

UniProt accession no.

Q8IZP0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)

関連するカテゴリー

Immunogen

ヒトABI1のアミノ酸163~180に相当する合成ペプチドのKLH結合体。この配列はマウス、ラット、イヌなどの複数の種で同一です。

Physical form

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

Application

Anti-ABI1 antibody produced in rabbit has been used in western blot analysis and immunofluorescence.
Rabbit anti- ABI1 antibody can be used for immunoblotting assays at a concentration of 0.5-1.0μg/ml using extracts from A431 and rat brain cells.

Biochem/physiol Actions

Abelson interactor 1 (Abi1) is essential for the formation and activation of WAVE2 signaling complex. ABI1 and WAVE are essential for Rac-dependent membrane protrusion and macropinocytosis, whereas ABI1 and N-WASP regulate actin-based vesicular transport, EGF receptor endocytosis, and EGFR and transferrin receptor (TfR) cell surface distribution. ABI1 has been shown to act as dual regulator of WAVE and neural Wiskott-Aldrich syndrome protein (N-WASP) specific activities. ABI1 is an essential component of this signaling complex. It positively regulates WAVE activity and connects WAVE to Rac through assembly of the WAVE-ABI1-Nap1-PIR121 complex. Abi1 modulates actin reorganization and lamellipodia formation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Abelson interactor 1 (Abi1) protein, a 65 kD-substrate of the eponymous Abelson non-receptor tyrosine kinase (c-Abl) is expressed mainly in the central nervous system. This gene is located on human chromosome 10p12.
Abi 1 is an adaptor protein that interacts with Wave2 to regulate actin polymerization.

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保管分類

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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試験成績書（COA）

Lot/Batch Number
0000133128
0000130036
076M4842V
097K4820

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文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Xing Judy Chen et al.
Developmental cell, 30(5), 569-584 (2014-09-10)
Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the
Upregulation of Abelson interactor protein 1 predicts tumor progression and poor outcome in epithelial ovarian cancer
Zhang J, et al.
Human Pathology, 46(9), 1331-1340 (2015)
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Innocenti M, et al.
Nature Cell Biology, 7(10), 969-976 (2005)
Decreased expression of cortactin in schizophrenia brain
Bhambhvani HP, et al.
Neuroreport, 27(3), 145-145 (2016)
ENL, the MLL fusion partner in t (11; 19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t (10; 11)+
Garcia-Cuellar MP, et al.
Oncogene, 19(14), 1744-1744 (2000)
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関連コンテンツ

Data Sheet - A5106

Instructions

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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