B0806
抗BACE 1, C末端(485-501)抗体 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous solution
別名:
抗β-部位APP切断酵素抗体
製品名
抗BACE 1, C末端(485-501)抗体 ウサギ宿主抗体, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 70 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
microarray: suitable
western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BACE1(23621)
関連するカテゴリー
Immunogen
ヒトBACE-1のC末端(アミノ酸 485-501)に相当する合成ペプチド。
Physical form
0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。
Application
Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Overexpression of β-site APP cleaving enzyme (BACE-1) leads to increased β-secretase activity while displaying appropriate cleavage site specificity for amyloid precursor protein (APP).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) is known as β-secretase. BACE-1 is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. It constitutes the predominant β-secretase activity in human brain tissue.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
S Prasad Gabbita et al.
PloS one, 10(10), e0137305-e0137305 (2015-10-06)
Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammation can be perpetuated by a cycle of
Marcus O W Grimm et al.
Scientific reports, 10(1), 9164-9164 (2020-06-10)
The vanilloid capsaicin is a widely consumed spice, known for its burning and "hot" sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence tau-pathology. Beside these positive effects, little is known about its
Marcus O W Grimm et al.
International journal of molecular sciences, 17(11) (2016-11-02)
One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms
Grimm MOW, et al.
Test, 286(16), 14028-14039 (2011)
Amanda Gonzales et al.
Journal of neuroscience methods, 202(1), 70-76 (2011-09-06)
The aspartyl protease BACE1 is the rate limiting enzyme in the synthesis of amyloid beta, which accumulation in the human brain is a hallmark of Alzheimer's disease (AD). BACE1 has been proposed as a surrogate marker of AD; however, very
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）