C0739
抗コルタクチン, リン酸化型(pTyr421)抗体 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous glycerol solution
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Species reactivity:
mouse
Citations:
12
Technique(s):
immunocytochemistry: suitable, western blot: 1:1,000
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 80-85 kDa
species reactivity
mouse
technique(s)
immunocytochemistry: suitable, western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr421)
Quality Level
Gene Information
mouse ... Cttn(13043)
関連するカテゴリー
Immunogen
マウスコルタクチンのチロシン421がリン酸化された領域に由来する合成リン酸化ペプチド。
Physical form
Mg2+/Ca2+不含D-PBS (pH 7.3 (+/- 0.1), 50%グリセロ-ル, 1.0mg/mL BSA(IgG/プロテア-ゼ不含), 0.05%アジ化ナトリウム含有)。
Application
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit is suitable for immunocytochemistry and western blotting at a working dilution of 1:1,000
Biochem/physiol Actions
Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.
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保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
C0739-BULK: + C0739-1VL-PW: + C0739-1VL: + C0739-VAR:
jan
Maxwell D Weidmann et al.
Scientific reports, 6, 36142-36142 (2016-11-09)
Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at tyrosine residues, in
Aviv Bergman et al.
Cell adhesion & migration, 8(3), 273-279 (2014-04-10)
Invadopodia are dynamic protrusions in motile tumor cells whose function is to degrade extracellular matrix so that cells can enter into new environments. Invadopodia are specifically identified by microscopy as proteolytic invasive protrusions containing TKS5 and cortactin. The increasing complexity
Tomer Meirson et al.
Oncotarget, 9(31), 22158-22183 (2018-05-19)
Metastatic dissemination of cancer cells from the primary tumor and their spread to distant sites in the body is the leading cause of mortality in breast cancer patients. While researchers have identified treatments that shrink or slow metastatic tumors, no
Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma.
Gang Zhao et al.
World journal of surgical oncology, 11, 74-74 (2013-03-23)
Cortactin is an important regulator involved in invasion and migration of hepatocellular carcinoma (HCC). The aim of this study was to elucidate the forecasting role of cortactin in resectable HCCs. We compared the invasiveness and motility among liver epithelial cell
Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival.
Cecilia Folio et al.
Cancer biomarkers : section A of Disease markers, 10(1), 35-41 (2012-02-03)
The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma. The location of CTTN at 11q13 and the role of cortactin in cytoskeleton restructuring make CTTN of interest as a potential biomarker for osteosarcoma.
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