C160

CGP-42112A

Name: CGP-42112A
Brand: SIGMA

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

別名:

N_α-ニコチノイル-Tyr-(N_α-Cbz-Arg)-Lys-His-Pro-Ile

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この商品について

実験式（ヒル表記法）:

C₅₂H₆₉N₁₃O₁₁

CAS番号:

127060-75-7

分子量:

1052.18

NACRES:

NA.77

PubChem Substance ID:

24892424

UNSPSC Code:

12352200

MDL number:

MFCD00133611

Beilstein/REAXYS Number:

8184948

主要文書

すべての文書を表示

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製品名

CGP-42112A, ≥95%, synthetic, solid

assay

≥95%

form

solid

color

white

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

biological source

synthetic

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

Application

CGP-42112A has been used:

in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

C160-1MG: + C1605-1MG-PW: + C160-BULK: + C160-VAR: + C160-1MG-PW: + C160-5MG:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

0000511932

0000484342

0000492066

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Role for stress fiber contraction in surface tension development and stretch-activated channel regulation in C2C12 myoblasts.

Francesca Sbrana et al.

American journal of physiology. Cell physiology, 295(1), C160-C172 (2008-05-16)

Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave

Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats.

Claudia A McCarthy et al.

Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)

We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect

Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.

Liping Zhu et al.

American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)

ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma

Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors.

L Laflamme et al.

The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)

In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level

Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.

C Sumners et al.

Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)

Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

サイズを選択してください

この商品について

主要文書

特性

製品名

assay

form

color

InChI key

SMILES string

InChI

biological source

storage temp.

Quality Level

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

安全性情報

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

C160-1MG: + C1605-1MG-PW: + C160-BULK: + C160-VAR: + C160-1MG-PW: + C160-5MG:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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