C1608
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse
clone C-1, ascites fluid, buffered aqueous solution
別名:
Anti-CRABP 1
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この商品について
Conjugate:
unconjugated
Clone:
C-1, monoclonal
Application:
ELISA (i), WB
Species reactivity:
feline, turtle, monkey, rabbit, bovine, human, rat, chicken
Citations:
9
Technique(s):
indirect ELISA: suitable, western blot: suitable
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
C-1, monoclonal
form
buffered aqueous solution
mol wt
antigen 16 kDa
species reactivity
feline, turtle, monkey, rabbit, bovine, human, rat, chicken
should not react with
(chameleon), frog, goldfish
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRABP1(1381)
rat ... Crabp1(25061)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse is suitable for the following applications:
- indirect ELISA
- western blotting at a dilution of 1:1000
- immunofluorescence at a working dilution of 1:250
Biochem/physiol Actions
Cellular retinoic acid-binding protein 1 (CRABP1) is a prognostic marker for adenocarcinoma and clear cell carcinoma that exhibits chemo-resistance. It is a is a modulator of retinoic acid and plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 also functions as a tumor-suppressor in esophageal epithelium and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Cellular retinoic acid-binding protein 1 is a protein encoded by the CRABP1 gene in humans. It encodes a specific binding protein for a vitamin A family member. It is also referred as RBP5, CRABP, CRABPI and CRABP-I.
Immunogen
performic acid oxidized CRABP 1, purified from bovine retina.
Physical form
Solution in phosphate buffered saline containing 0.05% sodium azide.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
C1608-BULK: + C1608-VAR: + C1608-100UL-PW: + C1608-100UL:
jan
Yu-Lung Lin et al.
Endocrinology, 158(9), 3004-3014 (2017-09-16)
Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is also known to elicit nongenomic RAR-independent activities, most widely detected in
Sung Wook Park et al.
The Journal of endocrinology, 236(3), 151-165 (2018-01-27)
Excessive and/or persistent activation of calcium-calmodulin protein kinase II (CaMKII) is detrimental in acute and chronic cardiac injury. However, intrinsic regulators of CaMKII activity are poorly understood. We find that cellular retinoic acid-binding protein 1 (CRABP1) directly interacts with CaMKII
Yi-Chiung Hsu et al.
Molecular carcinogenesis, 62(12), 1935-1946 (2023-08-29)
Cellular retinoic acid binding protein 1 (CRABP1) participates in the regulation of retinoid signaling. Previous studies showed conflicting results regarding the role of CRABP1 in tumor biology, including protumorigenic and tumor-suppressive effects in different types of cancer. Our bioinformatics analyses
M W Kelley et al.
Development (Cambridge, England), 119(4), 1041-1053 (1993-12-01)
The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length.
Shawna D Persaud et al.
Scientific reports, 6, 22396-22396 (2016-03-05)
All trans retinoic acid (atRA) is one of the most potent therapeutic agents, but extensive toxicity caused by nuclear RA receptors (RARs) limits its clinical application in treating cancer. AtRA also exerts non-genomic activities for which the mechanism remains poorly
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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