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Merck

C2993

抗CRMP2 ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

Anti-Collapsin Response Mediator Protein 2 (CRMP2), Anti-Dihydropyriminidase Related Protein-2 (DRP2, DRP-2, DHPRP2), Anti-Dihydropyriminidase-Like2 (DPYSL2), Anti-TOAD-64

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03456049

主要文書

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製品名

抗CRMP2 ウサギ宿主抗体, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~62 kDa

species reactivity

human, mouse, rat

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

western blot: 0.1-0.2 μg/mL using HeLa whole cell lysate and mouse brain extract (S1 fraction)

UniProt accession no.

Q16555

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... DPYSL2(1808)
mouse ... Dpysl2(12934)
rat ... Dpysl2(25416)

関連するカテゴリー

Application

Anti-CRMP2 antibody produced in rabbit has been used in:
  • western blotting
  • immunohistofluorescence
  • epifluorescence imaging
  • coimmunoprecipitation

Biochem/physiol Actions

CRMPs are a part of the collapsin/semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. CRMP2 is upregulated during development, and appears to be crucial for axon outgrowth. Glycogen synthase kinase 3 beta (GSK-3b) phosphorylates and inactivates CRMP-2 downstream of the phosphoinositide-3-kinase (PI3K/Akt) pathway, thus regulating neuronal polarity. CRMP2 interacts with tubulin dimers, kinesin-1 and WASP-family verprolin homologous protein 1 (WAVE1) complex to regulate axon outgrowth.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Collapsin response mediator proteins CRMPs) consist of a family of cytosolic phosphoproteins expressed in the nervous system and involved in neuronal differentiation and axonal guidance.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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保管分類

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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試験成績書（COA）

Lot/Batch Number
0000519190
0000519190
0000440364
0000440364
0000217355

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文書ライブラリにアクセスする

Aubin Moutal et al.
Pain, 157(7), 1448-1463 (2016-03-12)
Chronic pain affects the life of millions of people. Current treatments have deleterious side effects. We have advanced a strategy for targeting protein interactions which regulate the N-type voltage-gated calcium (CaV2.2) channel as an alternative to direct channel block. Peptides
CRMP2 phosphorylation drives glioblastoma cell proliferation
Moutal A, et al.
Molecular Neurobiology, 55(5), 4403-4416 (2018)
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain
Moutal A, et al.
Pain reports, 1(1) (2016)
Aubin Moutal et al.
Frontiers in cellular neuroscience, 8, 471-471 (2015-02-13)
The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein's cationic cell penetrating peptide (CPP) motif protected neurons in the face
Jennifer Y Xie et al.
Pain, 157(9), 2124-2140 (2016-08-19)
Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action
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