C3909
D-シクロセリン
synthetic
別名:
(R)-4-アミノ-3-イソオキサゾリドン, 4-アミノ-3-イソオキサゾリジノン
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この商品について
実験式（ヒル表記法）:
C3H6N2O2
CAS番号:
分子量:
102.09
UNSPSC Code:
12352209
NACRES:
NA.28
PubChem Substance ID:
EC Number:
200-688-4
Beilstein/REAXYS Number:
80798
MDL number:
biological source
synthetic
Quality Level
form
powder
mp
147 °C (dec.) (lit.)
solubility
water: 50 mg/mL, clear, colorless to light yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
cell wall synthesis | interferes
storage temp.
−20°C
SMILES string
N[C@@H]1CONC1=O
InChI
1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChI key
DYDCUQKUCUHJBH-UWTATZPHSA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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General description
Chemical structure: amino acid derivatives
Application
D-cycloserine has been used to inhibit serine hydroxymethyltransferase.
Biochem/physiol Actions
作用機序：細胞壁生合成を阻害（D-アラニン ペプチド結合形成）。また、D-アラニンからL-アラニンへの変換を妨げます。静菌性。
NMDAグルタミン酸作動性受容体のグリシン修飾部位の半アゴニスト；グラム陽性細菌に対する抗生物質。
抵抗性機序：D-アラニン輸送の妨害
NMDAグルタミン酸作動性受容体のグリシン修飾部位の半アゴニスト；グラム陽性細菌に対する抗生物質。
抵抗性機序：D-アラニン輸送の妨害
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Rick Richardson et al.
Learning & memory (Cold Spring Harbor, N.Y.), 11(5), 510-516 (2004-10-07)
Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of
Stefan G Hofmann et al.
The American journal of psychiatry, 170(7), 751-758 (2013-04-20)
The authors examined whether D-cycloserine, a partial agonist at the glutamatergic N-methyl-d-aspartate receptor, augments and accelerates a full course of comprehensive cognitive-behavioral therapy (CBT) in adults with generalized social anxiety disorder. This was a multisite randomized placebo-controlled efficacy study with
Stefan G Hofmann et al.
CNS drug reviews, 12(3-4), 208-217 (2007-01-18)
Anxiety disorders are among the most common mental disorders. One of the most effective strategies to treat anxiety disorders is exposure therapy with or without cognitive intervention. Fear reduction in exposure therapy is similar to extinction learning. Preclinical studies suggest
Marta Portero-Tresserra et al.
Neurobiology of learning and memory, 100, 1-11 (2012-12-04)
It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or
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