C4490
抗カベオリン1 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous solution
別名:
抗カベオリン1, 抗VIP21抗体
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
17
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
human, rat, mouse
technique(s)
indirect immunofluorescence: 4-8 μg/mL using HUVEC cell line, indirect immunofluorescence: suitable, western blot: 1-2 μg/mL using whole cell extract of the human endothelial ECV304 cell line and the mouse fibroblast NIH3T3 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
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関連するカテゴリー
General description
Caveolin, a 20-24 kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (CAV1) (20- 22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA. Caveolin-1 and -2 have similar tissue distribution.
Immunogen
ヒトカベオリン-1のN末端領域(アミノ酸2-20)に相当する合成ペプチド。
Application
Anti-Caveolin-1 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
この配列はラット, マウス, ウシ, イヌのカベオリン-1と同一であり、多くの生物種で高度に保存されています。また、この配列はカベオリン-2, カベオリン-3には存在しません。
Caveolin can simultaneously recognize GPI-linked proteins and interact directly with a number of caveolae associated downstream signaling molecules, such as H-Ras, hetero-trimeric G-proteins, annexin-II, epidermal growth factor receptor (EGFR), protein kinase C, src-family tyrosine kinases and nitric oxide synthase (NOS) isoforms. Caveolin-1 participates in angiogenesis and is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism by controlling the expression of glucose transporters.
Physical form
0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
C4490-200UL: + C4490-BULK: + C4490-VAR:
jan
Masashi Ogasawara et al.
Acta neuropathologica communications, 10(1), 176-176 (2022-12-09)
Oculopharyngodistal myopathy (OPDM) and oculopharyngeal muscular dystrophy (OPMD) are similar and even believed to be indistinguishable in terms of their myopathological features. To address the diagnostic gap, we evaluated the muscle biopsy samples for p62 expression by immunohistochemistry and compared
Brian C Russo et al.
mBio, 10(3) (2019-05-30)
Many Gram-negative bacterial pathogens require a type 3 secretion system (T3SS) to deliver effector proteins into eukaryotic cells. Contact of the tip complex of the T3SS with a target eukaryotic cell initiates secretion of the two bacterial proteins that assemble
Ingrid R Niesman et al.
Molecular and cellular neurosciences, 56, 283-297 (2013-07-16)
Microglia are ramified cells that serve as central nervous system (CNS) guardians, capable of proliferation, migration, and generation of inflammatory cytokines. In non-pathological states, these cells exhibit ramified morphology with processes intermingling with neurons and astrocytes. Under pathological conditions, they
Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes
Fernandez RJM, et al.
Nutrition & Metabolism, 7(1), 20-20 (2010)
Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
Yun JH, et al.
Experimental & Molecular Medicine, 43(12), 660-660 (2011)
関連コンテンツ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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