General description
A mixture of type I (containing α-hydroxy fatty acid) and type II (containing non-hydroxy fatty acid) cerebrosides. Galactocerebroside (GalCer) is a glycosphingolipid, that consists of a single galactose residue, connected to ceramide . GalCer is present within the exofacial leaflet of the lipid bilayer.
Application
Galactocerebrosides from bovine brain has been used to find the receptor activity of surface-immobilized galactosylceramide. It has also been used in sulfatide binding assay.
Biochem/physiol Actions
β-グリコシド結合でセラミドに結合したガラクト-スです。成体脳の主要脂質で、総脂質量の約16%を占めます。主にミエリンに局在し、脱髄性疾患にて顕著に減少します。
Galactocerebroside (GalCer) participates in the progression and maintenance of myelin. This oligodendroglial lipid is used as an immunohistochemical tool for studying oligodendrocytes.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
C4905-100MG: + C4905-1G: + C4905-10MG: + C4905-25MG: + C4905-500MG: + C4905-BULK: + C4905-VAR:
jan
Scaffold-forming and adhesive contributions of synthetic laminin-binding proteins to basement membrane assembly
McKee K K, et al.
The Journal of Biological Chemistry, 284(13), 8984-8994 (2009)
Oligodendrocyte morphology
Encyclopedia of Neuroscience (2009)
Piglet ileal mucus contains protein and glycolipid (galactosylceramide) receptors specific for Escherichia coli K88 fimbriae.
Blomberg L, et al.
Infection and Immunity, 61(6), 2526-2531 (1993)
Gangliosides and Autoimmune Peripheral Nerve Diseases
Progress in Molecular Biology and Translational Science, 156, 355-382 (2018)
F Persat et al.
Infection and immunity, 64(9), 3682-3687 (1996-09-01)
The effect on human peripheral blood mononuclear cells (PBMCs) of neutral glycosphingolipids extracted from metacestodes of the parasite Echinococcus multilocularis was investigated. Neutral glycosphingolipids inhibited [3H]thymidine uptake by human PBMCs upon stimulation by mitogens such as phytohemagglutinin A and pokeweed
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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