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C5865

CD437

Name: CD437
Brand: SIGMA

≥98% (HPLC), retinoic acid receptor (RAR)γ-selective agonist, solid

別名:

6-[3-(1-アダマンチル)-4-ヒドロキシフェニル]-2-ナフタレンカルボン酸, AHPN

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この商品について

実験式（ヒル表記法）:

C₂₇H₂₆O₃

CAS番号:

125316-60-1

分子量:

398.49

UNSPSC Code:

12352200

PubChem Substance ID:

24724445

NACRES:

NA.77

MDL number:

MFCD03106506

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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特性

製品名

CD437, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

impurities

~0.5 mol/mol water

color

yellow

mp

271.6-276 °C

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5

InChI

1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChI key

LDGIHZJOIQSHPB-UHFFFAOYSA-N

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

詳細

Biochem/physiol Actions

CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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試験成績書（COA）

Lot/Batch Number

0000382584

0000181995

0000139873

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以前この製品を購入いただいたことがある場合

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Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis.

Fang Tan et al.

Frontiers in microbiology, 10, 2301-2301 (2019-10-28)

Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.

Almudena Bosch et al.

Breast cancer research : BCR, 14(4), R121-R121 (2012-08-28)

Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and

Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA.

Liyue Zhang et al.

Journal of molecular signaling, 5, 12-12 (2010-08-14)

A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their