C6499
CTB
≥98% (HPLC)
別名:
N-(4-クロロ-3-トリフルオロメチル-フェニル)-2-エトキシ-ベンズアミド;N-[4-クロロ-3-(トリフルオロメチル)フェニル]-2-エトキシ-ベンズアミド;
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この商品について
実験式（ヒル表記法）:
C16H13ClF3NO2
CAS番号:
分子量:
343.73
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
InChI key
YDXZSNHARVUYNM-UHFFFAOYSA-N
General description
CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.
Application
CTB has been used to study its apoptotic effects on P53 protein acetylation.
Biochem/physiol Actions
CTPBは、ヒストンアセチルトランスフェラーゼp300のアクチベーターとして初めて知られた低分子化合物です。CTBは、CTPBと同程度かあるいはそれ以上の活性を発揮するCTPBの単純化アナログです。この化合物は、p300/EP300/E1A結合タンパク質のHAT活性を賦活化します。現在、その他HATアクチベーターは取り扱っておりません。
ヒストンアセチルトランスフェラーゼ(HAT)p300/CBP(CREB結合タンパク質)のアクチベーターです。
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
保管分類
11 - Combustible Solids
wgk
WGK 2
資料
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
Willian S Korim et al.
Cardiovascular research, 115(6), 1092-1101 (2018-10-26)
Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are
DeMetris D Reed et al.
Meat science, 123, 205-210 (2016-10-19)
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
Cory Chew et al.
Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)
Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and