CS0010
β-セクレターゼ(BACE1)活性蛍光検出キット
1 kit sufficient for 250 reactions
別名:
BACE1活性検出キット (蛍光)
製品名
β-セクレターゼ(BACE1)活性蛍光検出キット, 1 kit sufficient for 250 reactions
usage
kit sufficient for 250 reactions
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... BACE1(23621)
Application
本キットにはBACE1活性を効率的に検出するために必要な試薬がすべて揃っています。BACE1インヒビタ-の候補物質のスクリ-ニングに使用するための酵素も入っています。このアッセイでは、BACE1による基質切断後に観察される蛍光シグナルの増強を、蛍光共鳴エネルギ-移動(FRET)法で測定します。
Biochem/physiol Actions
BACE1は、アミロイド前駆体タンパク質(APP)のβ切断に関与する膜貫通型のプロテアーゼであり、アミロイドβペプチド(Aβ)が生成します。脳のAβ蓄積は、アルツハイマー病進行の主な原因です。BACE1はインヒビター創薬のターゲットです。
保管分類
10 - Combustible liquids
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Bioorganic chemistry, 90, 103062-103062 (2019-06-21)
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Changxing Qi et al.
Fitoterapia, 130, 134-139 (2018-08-31)
Terrusnolides A-D (1-4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of 1-4 were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that 1 was a butenolide derived by
Raúl Horacio Camarillo-López et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-04)
Alzheimer's disease (AD) is a neurodegenerative disease with no cure nowadays; there is no treatment either to prevent or to stop its progression. In vitro studies suggested that tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl) carbamate named the M4 compound can act as both β-secretase and
L Hong et al.
Biochemical Society transactions, 30(4), 530-534 (2002-08-28)
As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for
Lucas J Gutierrez et al.
Journal of biomolecular structure & dynamics, 35(2), 413-426 (2016-01-28)
We report here two new small-size peptides acting as modulators of the β-site APP cleaving enzyme 1 (BACE1) exosite. Ac-YPYFDPL-NH2 and Ac-YPYDIPL-NH2 displayed a moderate but significant inhibitory effect on BACE1. These peptides were obtained from a molecular modeling study.
関連コンテンツ
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