D0390
NG,NG′-ジメチル-L-アルギニン ジ(p-ヒドロキシアゾベンゼン-p′-スルホン酸)塩
≥99% (TLC)
別名:
SDMA
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この商品について
実験式（ヒル表記法）:
C8H18N4O2 · 2C12H10N2O4S
CAS番号:
分子量:
758.82
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
SMILES string
CN\C(NC)=N\CCC[C@H](N)C(O)=O.Oc1ccc(cc1)\N=N\c2ccc(cc2)S(O)(=O)=O.Oc3ccc(cc3)\N=N\c4ccc(cc4)S(O)(=O)=O
InChI
1S/2C12H10N2O4S.C8H18N4O2/c2*15-11-5-1-9(2-6-11)13-14-10-3-7-12(8-4-10)19(16,17)18;1-10-8(11-2)12-5-3-4-6(9)7(13)14/h2*1-8,15H,(H,16,17,18);6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/b2*14-13+;/t;;6-/m..0/s1
InChI key
HISUXCNNXYEHER-YJSASASGSA-N
biological source
synthetic (organic)
assay
≥99% (TLC)
form
powder
solubility
methanol: 10 mg/mL
storage temp.
room temp
Quality Level
Application
血漿中のsym-ジメチルアルギニンは、肝および腎機能不全のマーカーと考えられています。血漿と尿検体中の、アルギニンとasym-およびsym-ジメチルアルギニンを同定する高感度LC-MS法が開発されています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
D0390-BULK: + D0390-100MG: + D0390-VAR: + D0390-1MG: + D0390-5MG: + D0390-25MG:
jan
Bob Siegerink et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 102(3), 193-202 (2012-10-18)
Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been associated with total and cardiovascular mortality in various clinical settings. Studies on its structural isomer, symmetric dimethylarginine (SDMA), are scarce. This study aimed to determine the associations
Guozhen Gao et al.
Nucleic acids research, 45(8), 4359-4369 (2017-01-25)
The type II arginine methyltransferase PRMT5 is responsible for the symmetric dimethylation of histone to generate the H3R8me2s and H4R3me2s marks, which correlate with the repression of transcription. However, the protein level of a number of genes (MEP50, CCND1, MYC
D P Dahlem et al.
Journal of veterinary internal medicine, 31(3), 799-804 (2017-04-04)
Symmetric dimethylarginine (SDMA) is considered a biomarker for early detection of renal dysfunction in human patients with acute kidney injury (AKI). At present, no studies exist analyzing the relevance of SDMA in dogs with AKI. SDMA would correctly identify dogs
Lena Pelander et al.
Journal of veterinary internal medicine, 33(2), 630-639 (2019-02-23)
Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required. To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection
Jane Yu et al.
Animals : an open access journal from MDPI, 10(6) (2020-06-12)
The pharmacokinetic profile of mefloquine was investigated as a preliminary study towards a potential treatment for feline coronavirus infections (such as feline infectious peritonitis) or feline calicivirus infections. Mefloquine was administered at 62.5 mg orally to seven clinically healthy cats
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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