D8040
(±)-trans-U-50488 メタンスルホン酸塩
別名:
trans-(±)-3,4-ジクロロ-N-メチル-N-[2-(1-ピロリジニル)シクロヘキシル]ベンゼンアセトアミド メタンスルホン酸塩, U-50488H
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この商品について
実験式（ヒル表記法）:
C19H26Cl2N2O · CH4O3S
分子量:
465.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
InChI
1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1
SMILES string
CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI key
OJPHNZCUXUUVKU-JAXOOIEVSA-N
form
powder
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... OPRK1(4986)
Application
(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.
Biochem/physiol Actions
Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
D8040-50MG: + D8040-100MG: + D8040-10MG: + D8040-10MG-PW: + D8040-VAR: + D8040-100MG-PW: + D8040-BULK: + D8040-50MG-PW:
jan
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
Beardsley PM, et al.
Psychopharmacology, 183(1), 118-118 (2005)
Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
Chajra H, et al.
International Journal of Cosmetic Science, 37(4), 386-394 (2015)
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
Basile AS, et al.
Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)
Guang-Jie Gao et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 2868135-2868135 (2022-08-30)
Acute lung injury (ALI) is one of the common and severe complications of cardiopulmonary bypass (CPB), which is the primary cause of death in intensive care units. Nevertheless, there is a lack of effective treatment for ALI secondary to CPB.
Moriah L Jacobson et al.
Psychopharmacology, 237(12), 3715-3728 (2020-09-08)
Major depressive disorder is a leading cause of disability worldwide and is likely precipitated by chronic stress. Although many antidepressants are currently available, these drugs require weeks to months of daily administration before reduction of symptoms occurs and many patients
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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