D8946
DMH1
≥98% (HPLC), powder, BMP inhibitor
別名:
4-[6-(4-イソプロポキシフェニル)ピラゾロ[1,5-a]ピリミジン-3-イル]キノリン, 4-[6-[4-(1-メエチルエトキシ)フェニル]ピラゾロ[1,5-a]ピリミジン-3-イル]-キノリン
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
実験式（ヒル表記法）:
C24H20N4O
CAS番号:
分子量:
380.44
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
DMH1, ≥98% (HPLC)
SMILES string
CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3
InChI key
JMIFGARJSWXZSH-UHFFFAOYSA-N
InChI
1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to orange
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Application
DMH1は、骨形成タンパク質（BMP）の阻害に使用されます。 また、血管内皮成長因子（VEGF）シグナルの阻害にも使用されています。
Biochem/physiol Actions
DMH1は、高選択的骨形成タンパク質(BMP)インヒビターです。
DMH1は、高選択的骨形成タンパク質(BMP)インヒビターです。DMH1はドルソモルフィンのアナログですが、BMPのみを標的としており、VEGF経路には作用しません。
General description
DMH1は、ヒト人工多能性幹細胞（hiPSC）の神経形成を刺激し、また、肺癌の増殖と転位を抑えます。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Richard H Row et al.
eLife, 7 (2018-06-08)
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs)
José M Martín-Durán et al.
Nature, 553(7686), 45-50 (2017-12-14)
It has been hypothesized that a condensed nervous system with a medial ventral nerve cord is an ancestral character of Bilateria. The presence of similar dorsoventral molecular patterns along the nerve cords of vertebrates, flies, and an annelid has been
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
Kwang Bo Jung et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(1), 111-122 (2017-09-01)
Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system is needed for visualizing the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here
DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）