モノクロナール抗CD3

CD3複合体を認識します。クロ-ン番号UCHT-1のモノクロ-ナル抗体によって認識されるエピト-プは、CD3抗原/T細胞レセプタ-複合体のε鎖上に発現しています。3rd Workshop: code no. 126, 208 and 471
4th Workshop: paper no. T3.2

CD3複合体(16/20/29/22/25~28 kDa)は、たがいに結合した5本のポリペプチド鎖からなり、T細胞レセプタ-と結合します。

CD3e molecule, ε (CD3E) is a polypeptide encoded by the CD3E gene in humans. It resides on chromosome 11. The CD3ε cytoplasmic domain of the T cell receptor binds to the inner leaflet of the plasma membrane (PM) and is accessible during early stages of T cell activation. It is specific for T lymphocytes and is found in Purkinje cells of the cerebellum as well as in gastric parietal cells of humans and other species. Cytoplasmic cyCD3 expression can only be seen during the early phase of NK-cell differentiation.

ヒト胸腺細胞、セザリ-T細胞。

Monoclonal Anti-CD3-FITC antibody produced in mouse is suitable for flow cytometry (at a dilution of 10μL using 1 × 106 cells). It was also used for ADCC Assay.

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Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Prepared by conjugation to fluorescein isothiocyanate isomer I (FITC). This green dye is efficiently excited at 495 nm and emits at 525 nm.