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Merck

F5421

抗線維芽細胞増殖因子受容体1 ウサギ宿主抗体

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

抗FGFR-1抗体

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この商品について

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD00675556
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), IP, WB
Citations:
9

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 110-120 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections, immunoprecipitation (IP): suitable, western blot: 1:400 using an extract of FGFR-1 transfected cells

UniProt accession no.

P11362

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... FGFR1(2260)

関連するカテゴリー

General description

Fibroblast growth factor receptor 1 (FGFR-1) belongs to the family of FGFRs. At the mRNA level, FGFR-1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates.

Immunogen

Synthetic peptide corresponding to amino acid residues 360-373 of the extracellular region of human FGFR-1 conjugated to KLH with glutaraldehyde, and with a C-terminally added lysine.

Application

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunofluorocytochemistry
  • immunohistochemistry
  • immunoblotting

Biochem/physiol Actions

FGFR-2 (Bek) およびFGFR-3との反応は検出されません。
Anti-FGFR-1 antibody is specific for human FGFR-1 and does not react with human FGFR-2 and FGFR-3. The immunizing peptide specifically inhibits the staining of anti-FGFR-1 antibody.
Staining of the product is specifically inhibited with the FGFR-1 immunizing peptide. No reaction with human FGFR-2 and FGFR-3 is detected.

Physical form

0.01M PBS溶液(pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

F5421-25UL: + F5421-VAR: + F5421-.2ML: + F5421-BULK:

jan

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試験成績書（COA）

Lot/Batch Number
0000465505
0000465505
0000129398
0000129398
0000129399

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文書ライブラリにアクセスする

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
Peters KG, et al.
Development, 114 (1992)
Wei Zheng et al.
Developmental neuroscience, 26(2-4), 181-196 (2005-02-16)
Cells within the subventricular zone (SVZ) express basic Fgf (Fgf2) and Fgf receptor proteins. We show that the absence of Fgf2 gene products reduces by 50% the dividing progenitor population of the anterior SVZ (SVZa) without changing their cell cycle
Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
Sleeman IJ, et al.
Neuropharmacology, 63 (2012)
Wattamon Srisakuldee et al.
Cells, 10(10) (2021-10-24)
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP. We addressed the hypothesis that the growth factor FGF2, known to reside in
Frank W King et al.
Stem cells and development, 18(10), 1441-1450 (2009-03-04)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. While subpopulations of hESCs within pluripotent cultures have been identified based on expression of specific surface antigens, their significance and fates are
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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