G8918
抗GRP78/BiP (GL-19)抗体 ウサギ宿主抗体
IgG fraction of antiserum, buffered aqueous solution
別名:
抗78-kDaグルコース調節タンパク質抗体, 抗イムノグロブリンH鎖結合タンパク質抗体
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, ICC, WB
Citations:
36
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 78 kDa
species reactivity
mouse, hamster, human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells, microarray: suitable, western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HSPA5(3309)
mouse ... Hspa5(14828)
General description
GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.
Application
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
Biochem/physiol Actions
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
Physical form
0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
G8918-BULK: + G8918-200UL: + G8918-VAR:
jan
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
Ouyang YB, et al.
Mitochondrion, 11(2), 279-286 (2011)
Henning G Hansen et al.
Bioscience reports, 34(2) (2014-04-01)
In the ER (endoplasmic reticulum) of human cells, disulfide bonds are predominantly generated by the two isoforms of Ero1 (ER oxidoreductin-1): Ero1α and Ero1β. The activity of Ero1α is tightly regulated through the formation of intramolecular disulfide bonds to help
Eva Ramon et al.
The Journal of biological chemistry, 289(52), 35918-35928 (2014-11-02)
Retinitis pigmentosa (RP) is a group of genetically and clinically heterogeneous inherited degenerative retinopathies caused by abnormalities of photoreceptors or retinal pigment epithelium in the retina leading to progressive sight loss. Rhodopsin is the prototypical G-protein-coupled receptor located in the
Mina Thon et al.
Scientific reports, 6, 34312-34312 (2016-09-30)
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not
GRP78 at the centre of the stage in cancer and neuroprotection
Casas, Caty
Frontiers in Neuroscience, 11, 177-177 (2017)
関連コンテンツ
Instructions
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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