G9665
抗グルタミン酸レセプター1A, 代謝調節型(mGluR1A)抗体 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous glycerol solution
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (frozen sections)
western blot
western blot
Species reactivity:
mouse, feline, rat
Citations:
15
Technique(s):
immunohistochemistry (frozen sections): 1:500
western blot: 1:1,000
western blot: 1:1,000
Uniprot accession no.:
製品名
抗グルタミン酸レセプター1A, 代謝調節型(mGluR1A)抗体 ウサギ宿主抗体, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, feline, rat
technique(s)
immunohistochemistry (frozen sections): 1:500
western blot: 1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Grm1(14816)
rat ... Grm1(24414)
関連するカテゴリー
Biochem/physiol Actions
この抗体は、その他のスプライスバリアントやmGluR5とは反応しません。
Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Mutations in this gene causes autosomal-recessive congenital cerebellar ataxia.
Immunogen
ラット代謝調節型グルタミン酸レセプタ-1A(mGluR1a)のアミノ酸配列1116-1130に相当する合成ペプチド。
Physical form
10mM HEPES (pH 7.5, 150mM NaCl, 100μg/mL BSA, 50%グリセロ-ル含有)。
Application
Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.
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保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
G9665-BULK: + G9665-.1ML: + G9665-VAR: + G9665-.1ML-PW:
jan
Tatjana Surdin et al.
iScience, 26(1), 105828-105828 (2023-01-13)
Neuronal plasticity underlying cerebellar learning behavior is strongly associated with type 1 metabotropic glutamate receptor (mGluR1) signaling. Activation of mGluR1 leads to activation of the Gq/11 pathway, which is involved in inducing synaptic plasticity at the parallel fiber-Purkinje cell synapse
Huixian Wu et al.
Science (New York, N.Y.), 344(6179), 58-64 (2014-03-08)
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are class C G protein-coupled receptors (GPCRs). We determined the structure of the human mGlu1 receptor seven-transmembrane (7TM) domain bound to a negative allosteric modulator, FITM
Sonja Janmaat et al.
The Journal of comparative neurology, 512(4), 467-477 (2008-11-26)
In vivo, homozygous staggerer (Rora(sg/sg)) Purkinje cells (PCs) remain in an early stage of development with rudimentary spineless dendrites, associated with a lack of parallel fiber (PF) input and the persistence of multiple climbing fibers (CFs). In this immunocytochemical study
Kunie Sakurai et al.
Developmental neurobiology, 69(12), 811-824 (2009-08-13)
The neural cell recognition molecule NB-3, also referred to as contactin-6, is expressed prominently in the developing nervous system after birth and its deficiency has been shown to cause impairment in motor coordination. Here, we investigated the contribution of NB-3
Velina Guergueltcheva et al.
American journal of human genetics, 91(3), 553-564 (2012-08-21)
Autosomal-recessive congenital cerebellar ataxia was identified in Roma patients originating from a small subisolate with a known strong founder effect. Patients presented with global developmental delay, moderate to severe stance and gait ataxia, dysarthria, mild dysdiadochokinesia, dysmetria and tremors, intellectual
関連コンテンツ
Instructions
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