モノクロナール抗HLAクラスI抗原 マウス宿主抗体

Class I proteins are highly polymorphic, in which HLA-B seems to be the most polymorphic gene in the human genome. HLA-A, -B, -C are classical class I proteins and are heterodimers. HLA-A, -B, -C consists of a polymorphic transmembrane α heavy chain and an invariant water-soluble light chain. HLA-B is located on human chromosome 6p21.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

ヒト扁桃白血球膜調製物。

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

大部分のヒト有核細胞で発現するヒトHLAクラスI抗原を認識します。本抗体は、ヒトHLAクラスＩ分子 (HLA-A,B,C) の44-45 kDaα鎖ポリペプチドに存在する単形性エピト-プと反応します。本抗体は、免疫沈降法、補体依存性細胞障害試験、フロ-サイトメトリ-、免疫組織化学染色 (アセトン固定, 凍結切片, 塗沫細胞) にご使用いただけます。 アフリカ、アジアの類人猿や旧世界猿の細胞に交差反応性を示します。大部分の新世界猿や非霊長類について、細胞との反応性は認められません。本抗体が認識するエピト-プは、通常のホルマリン固定、パラフィン包埋に対し不安定です。
4th Workshop: code no. P1
5th Workshop: code nos. BP166, BP288, BP407, B 005

HLA class I molecules like HLA-A, -B and −C help in the presentation of endogenous antigen to CD8+ (cluster of differentiation 8) T cells.

0.01 M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)

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