I2764
ML-7
≥98% (TLC), myosin light chain kinase inhibitor, powder
別名:
1-(5-ヨードナフタレン-1-スルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン 塩酸塩
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この商品について
実験式（ヒル表記法）:
C15H17IN2O2S · HCl
CAS番号:
分子量:
452.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
ML-7, powder
SMILES string
Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
KDDALCDYHZIZMH-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
color
white
solubility
ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Gene Information
human ... MYLK(4638), MYLK2(85366)
関連するカテゴリー
Application
ML-7は、さまざまな実験でミオシン軽鎖キナーゼ（MLCK）阻害剤として使用されています。
Biochem/physiol Actions
ミオシン軽鎖キナ-ゼの選択的インヒビタ-です。
Features and Benefits
この化合物は、Handbook of Receptor Classification and Signal Transduction（受容体分類およびシグナル伝達ハンドブック）のCa/CaMKのページに記載されています。ハンドブックのその他のページをご覧になるには、こちらをクリックしてください。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Chuanjun Huang et al.
Molecular medicine reports, 17(5), 6293-6300 (2018-03-08)
Previous studies have indicated that smooth muscle myosin light chain kinase (MLCK) has a prominent role in the regulation of smooth muscle contraction, which tends to be upregulated in asthma. In recent years, numerous studies have reported that MLCK is
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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