I9905
インターロイキン-2/Fcキメラ(不溶性) マウス由来
>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution
別名:
IL-2:Fc(不溶性)
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この商品について
Biological source:
mouse
Recombinant:
expressed in CHO cells
Assay:
>98% (SDS-PAGE)
Form:
solution
Mol wt:
94 kDa
Impurities:
endotoxin, tested
製品名
インターロイキン-2/Fcキメラ(不溶性) マウス由来, >98% (SDS-PAGE), recombinant, expressed in CHO cells, solution
biological source
mouse
recombinant
expressed in CHO cells
assay
>98% (SDS-PAGE)
form
solution
mol wt
94 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.1 mg/mL
impurities
endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Il2(16183)
Analysis Note
生物活性は、CTLL2細胞を用いた細胞増殖試験で測定されています。
Biochem/physiol Actions
IL-2部分の生物学的機能と、Fcドメインに起因する長い循環系内半減期とを有しています。
IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).
Other Notes
変異型マウスIgG2a Fcに融合したマウスIL-2からなる二量体融合タンパク質です。
Physical form
溶液(0.2μmフィルタ-で減菌濾過済み, PBS溶液, pH 7.4)。
保管分類
10 - Combustible liquids
R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various
Parul Mehra et al.
Molecular and cellular biology, 35(22), 3880-3891 (2015-09-10)
Interleukin-2 (IL-2) is a potent cytokine with roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role for Il2 in autoimmune disease susceptibility, and for decades the proximal Il2 upstream regulatory region has served as
関連コンテンツ
Datasheet
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