L6293
LY-364947
≥98% (HPLC), Transforming Growth Factor-β Type I receptor kinase (ALK5) inhibitor, powder
別名:
4-[3-(2-ピリジニル)-1H-ピラゾール-4-イル]-キノリン, HTS 466284, トランスフォーミング増殖因子-β I型受容体キナーゼ阻害剤
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この商品について
実験式（ヒル表記法）:
C17H12N4
CAS番号:
分子量:
272.30
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
LY-364947, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
InChI
1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
InChI key
IBCXZJCWDGCXQT-UHFFFAOYSA-N
Gene Information
human ... TGFBR1(7046)
関連するカテゴリー
Biochem/physiol Actions
LY-364947は、IC50 = 59 nMのトランスフォーミング増殖因子-β I型受容体キナーゼ（TGF-β RI、ALK5）の選択的ATP競合阻害剤です。関連キナーゼでははるかに効力が低く、TGF-β RIIではIC50 = 400 nM、MAPキナーゼシグナル経路のキナーゼであり、TGF-β RIIと密接に関連する混合系統キナーゼ-7（MLK-7）ではIC50 = 1400 nMです。LY-364947は、NIH 3T3マウス線維芽細胞のTGF-β-依存性細胞増殖（IC50 = 81 nM）を阻害します。
トランスフォーミング増殖因子-β I型受容体キナーゼ（ALK5）阻害剤
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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