M2699
マリマスタット
≥98% (HPLC), solid, MMP inhibitor
別名:
BB2516;(2S,3R)-N4-[(1S)-2,2-ジメチル-1-[(メチルアミノ)カルボニル]プロピル]-N1,2-ジヒドロキシ-3-(2-メチルプロピル)ブタンジアミド
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この商品について
実験式（ヒル表記法）:
C15H29N3O5
CAS番号:
分子量:
331.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
マリマスタット, ≥98% (HPLC)
SMILES string
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
InChI key
OCSMOTCMPXTDND-OUAUKWLOSA-N
InChI
1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥20 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
関連するカテゴリー
Application
マリマスタットは、下記の阻害薬として使用されています：
- マウスにおける運動誘発性インターロイキン-6（IL-6）放出に対する影響を検討するためのメタロプロテイナーゼ2/9（MMP2/9）
- Pseudomonas aeruginosa培養のプロテアーゼ活性を決定するためのメタロプロテイナーゼ
- モノクローナル抗体H3のメタロプロテイナーゼ10（MMP10）との結合に対する影響を検討するためのMMP10
Biochem/physiol Actions
マリマスタットは、広域スペクトルのマトリックスメタロプロテアーゼ(MMP)インヒビターです。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Amir S Razai et al.
The Journal of biological chemistry, 295(8), 2464-2472 (2020-01-19)
Since their discovery, the matrix metalloproteinase (MMP) family proteases have been considered as therapeutic targets in numerous diseases and disorders. Unfortunately, clinical trials with MMP inhibitors have failed to yield any clinical benefits of these inhibitors. These failures were largely
Stefanie K Menzies et al.
Toxicon: X, 14, 100118-100118 (2022-03-25)
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors and deplete fibrinogen. The only available treatment
Nicholas J Youngman et al.
Molecules (Basel, Switzerland), 27(5) (2022-03-11)
Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for the neutralisation of key snake venom toxins
Timothy W Failes et al.
Journal of inorganic biochemistry, 101(3), 396-403 (2007-01-02)
Fe(III)-salen (N,N-bis(salicylidene)-ethane-1,2-diimine) complexes of simple hydroxamic acids and the MMP (matrix metalloproteinase) inhibitor marimastat have been evaluated as hypoxia activated drug carriers. The aceto- (aha), propion- (pha), benzohydroxamato (bha), and marimastat complexes were prepared and characterised by single crystal X-ray
M Ohshima et al.
Journal of dental research, 89(11), 1315-1321 (2010-08-27)
The underlying mechanism and the therapeutic regimen for the transition of reversible gingivitis to irreversible periodontitis are unclear. Since transforming growth factor (TGF)-β has been implicated in differentially regulated gene expression in gingival fibroblasts, we hypothesized that TGF-β signaling is
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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