M7802
モノクロナール抗MAPキナーゼ, 活性化/モノリン酸化 (リン酸化トレオニン ERK-1&2) マウス宿主抗体
~2 mg/mL, clone ERK-PT115, purified immunoglobulin, buffered aqueous solution
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この商品について
Conjugate:
unconjugated
Clone:
ERK-PT115, monoclonal
Application:
ARR, ELISA (c), ICC, WB
Citations:
16
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
ERK-PT115, monoclonal
form
buffered aqueous solution
mol wt
antigen, ERK-1 44 kDa, antigen, ERK-2 42 kDa
species reactivity
rat, human
concentration
~2 mg/mL
technique(s)
capture ELISA: suitable, immunocytochemistry: suitable, microarray: suitable, western blot: 0.5 μg/mL using extract of a rat fibroblast cell line, Rat1, activated with sorbitol
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAPK1(5594), MAPK3(5595)
rat ... Mapk1(116590), Mapk3(50689)
関連するカテゴリー
General description
Activated/ Monophosphorylated (Phosphothreonine ERK-1&2) (mouse IgG1 isotype) is derived from the ERK-PT115 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Mitogen-activated protein kinase 1 (MAPK1) is mapped to human chromosome 22q11.22 and MAPK3 is present on human chromosome 16p11.2.
Immunogen
リン酸化型のERK活性化ル-プに相当する合成ペプチド(HTGFLpTEYVAT)。
Application
Monoclonal Anti-MAP Kinase, Activated/monophosphorylated (Phosphothreonine ERK-1&2) antibody produced in mouse has been used in:
- immunoblotting
- western blotting
- immunofluorescence
- enzyme linked immunosorbent assay (ELISA)
- immunochemistry
Biochem/physiol Actions
抗体は、スレオニン一リン酸化型および活性化された二リン酸化型のMAPキナ-ゼ(ERK-1, ERK-2)と特異的に反応します。非リン酸化型のMAPキナ-ゼ分子や二リン酸化型のJNKおよびp38 MAPKは認識されません。抗体が認識するエピト-プには、活性化MAPキナ-ゼの調節部位のリン酸化スレオニン残基(ERK-2の場合Thr183)が含まれています。
Physical form
0.01M PBS溶液(pH 7.4, 15mMアジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
M7802-BULK: + M7802-VAR: + M7802-.2ML:
jan
A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma
Kondapalli KC, et al.
Nature Communications, 6(5), 6289-6289 (2015)
Transcriptional consequences of 16p11. 2 deletion and duplication in mouse cortex and multiplex autism families
Blumenthal I, et al.
American Journal of Human Genetics, 94(6), 870-883 (2014)
Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients
Calati R, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 44, 271-278 (2013)
Frances Evans et al.
BioMed research international, 2021, 2641068-2641068 (2021-11-02)
Gramicidin is a thoroughly studied cation ionophore widely used to experimentally manipulate the plasma membrane potential (PMP). In addition, it has been established that the drug, due to its hydrophobic nature, is capable of affecting the organization of membrane lipids.
Leader cell positioning drives wound-directed collective migration in TGFbeta-stimulated epithelial sheets
Chapnick DA and Liu X
Molecular Biology of the Cell, 25(10), 1586-1593 (2014)
関連コンテンツ
Datasheet
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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