N216
モノクローナル抗Na+/Ca+交換体抗体 マウス宿主抗体
clone C2C12
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この商品について
Conjugate:
unconjugated
Clone:
C2C12, monoclonal
Application:
immunohistochemistry (frozen sections)
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Species reactivity:
human, rat, canine, rabbit, guinea pig
Citations:
19
Technique(s):
immunohistochemistry (frozen sections): 1:200
immunoprecipitation (IP): suitable
western blot: 1:1,000
immunoprecipitation (IP): suitable
western blot: 1:1,000
Uniprot accession no.:
製品名
モノクローナル抗Na+/Ca+交換体抗体 マウス宿主抗体, clone C2C12
biological source
mouse
conjugate
unconjugated
antibody product type
primary antibodies
clone
C2C12, monoclonal
form
liquid
mol wt
antigen 120 kDa (mature exchanger)
antigen 160 kDa (non-reduced)
antigen 70 kDa (proteolytic fragment)
species reactivity
human, rat, canine, rabbit, guinea pig
technique(s)
immunohistochemistry (frozen sections): 1:200
immunoprecipitation (IP): suitable
western blot: 1:1,000
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC8A1(6546)
関連するカテゴリー
Biochem/physiol Actions
抗体は、腎臓および心臓組織のNa+/Ca2+交換体と特異的に反応します。免疫組織化学において、形質膜の染色に加え、心臓T管膜に強い染色が認められます。この抗体は、ラット組織サンプルのイムノブロッティングには適していません。
Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+.
Immunogen
イヌ心臓Na+/Ca2+交換体。エピト-プは形質膜の細胞内側に位置するアミノ酸371-525の領域に存在しています。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.
Physical form
Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
N216-BULK: + N216-VAR: + N216-100UL-PW: + N216-100UL:
jan
Jia Chang et al.
The Journal of biological chemistry, 282(42), 30938-30948 (2007-08-28)
Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/beta-catenin signaling pathway has been found to play a critical role in skeletal
Hanxing Wan et al.
Oncogene, 41(35), 4169-4182 (2022-07-27)
Plasma membrane Na+/Ca2+ exchanger 1 (NCX1) is a bidirectional ion transporter to operate in Ca2+ entry or exit modes, and TRPC1 is Ca2+-permeable channel. Both NCX1 and TRPC1 play critical roles in maintaining cytosolic free Ca2+ ([Ca2+]cyt) homeostasis in mammalian
Julian Vallejo et al.
PloS one, 11(3), e0150066-e0150066 (2016-03-10)
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects
Sandhya Sriram et al.
Aging cell, 10(6), 931-948 (2011-07-21)
Abnormal levels of reactive oxygen species (ROS) and inflammatory cytokines have been observed in the skeletal muscle during muscle wasting including sarcopenia. However, the mechanisms that signal ROS production and prolonged maintenance of ROS levels during muscle wasting are not
Ping-Chun Li et al.
PloS one, 9(2), e85909-e85909 (2014-02-06)
Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(2+) exchanger (NCX) is a critical mediator of calcium
関連コンテンツ
Instructions
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