N4773
ニューロン特異的エノラーゼ ヒト脳由来
≥95% (SDS-PAGE), buffered aqueous solution
別名:
2-ホスホ-D-グリセリン酸ヒドロリアーゼ, NSE, エノラーゼ、ニューロン特異的 ヒト脳由来, 熱不安定性抗原A
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
Specific activity:
≥10 units/mg protein
Assay:
≥95% (SDS-PAGE)
Biological source:
human brain
biological source
human brain
assay
≥95% (SDS-PAGE)
form
buffered aqueous solution
specific activity
≥10 units/mg protein
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... ENO2(2026)
General description
Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.
Application
Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.
Biochem/physiol Actions
ニュ-ロン特異的エノラ-ゼ(NSE)は全ての神経細胞に発現され、その発現はシナプス機能を獲得していることを示します。急性神経細胞損傷後。神経細胞体ではNSEレベルが高まっています。血清や脳髄液中のNSE高値は、神経損傷および神経細胞死のマ-カ-として用いられています。たいていの神経細胞性腫瘍や神経内分泌腫瘍など、多くの細胞タイプから派生する腫瘍はNSEを発現します。
Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.
Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.
Physical form
0.1 M Tris-リン酸(pH 7.0)、0.2 M KCl、5 mM NgSO4の溶液
Other Notes
1 unitは、pH 7.4、25°C、1分間で、1.0 μmoleの2-ホスホグリセリン酸をホスホ(エノール)ピルビン酸に変換します。
保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
N4773-VAR: + N4773-10UG: + N4773-BULK: + N4773-10UG-PW:
jan
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects
Ai-tao Guo et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 41(11), 747-751 (2013-01-11)
To study the clinical and pathologic characteristics of small cell neuroendocrine carcinoma of urinary tract. All cases of urinary tract carcinoma encountered in the General Hospital of People Liberation Army during the period from 1999 to 2010 were retrospectively reviewed.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）