P1941
ポリ(D,L-ラクチド-コ-グリコリド)
lactide:glycolide (75:25), mol wt 66,000-107,000
別名:
LACTEL® B6007-1, PLGA
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この商品について
化学式:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.26
MDL number:
form
pellets
Quality Level
feed ratio
lactide:glycolide (75:25)
mol wt
66,000-107,000
storage temp.
−20°C
SMILES string
OCC(O)=O.CC(O)C(O)=O
InChI key
XBBVURRQGJPTHH-UHFFFAOYSA-N
General description
本製品は、転移温度（Tg）が45-50°Cの非晶質固体です。塩化メチレン、テトラヒドロフラン、エチルアセテート、アセトン、クロロホルム、ヒキサフルオロイソプロパノール等のほとんどの有機溶媒に可溶です。.
Application
ポリ(D、L-ラクチドcoグリコリド)は、高分子治療学のために使用されてきた合成アミノ酸です。
Features and Benefits
生物活性剤の制御された放出、縫合や生体吸収性の移植可能なデバイス。
Physical form
生体適合性、生物分解性ポリマ-。
Legal Information
Lactel is a registered trademark of Evonik Corp
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
資料
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
生分解性脂肪族ポリエステルはDDS分野での抗がん剤送達用途で注目されており、ポリエステルの合成、刺激応答性薬物担体、能動的標的化を中心に詳細をご紹介します。
Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo
Werner E.G.Muller
Acta Biomaterialia, 50, 89-101 (2017)
Robert M Stefani et al.
Acta biomaterialia, 102, 326-340 (2019-12-06)
Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative