P1995
抗ポドプラニン(HG-19)抗体 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous solution
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
10
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~38 kDa
species reactivity
rat
technique(s)
indirect immunofluorescence: 10-20 μg/mL using rat kidney frozen sections, western blot (chemiluminescent): 2.5-5 μg/mL using whole extract of rat kidney glomeruli and rat lung
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Pdpn(54320)
関連するカテゴリー
General description
Podoplanin is part of the type-1 transmembrane sialomucin-like glycoprotein family. The gene encoding this 43kDa protein is localized on rat chromosome 5.
Podoplanin is present on the surface of podocytes in kidney glomeruli and the parietal cells of the glomerular Bowman′s capsule. It is also named E11 antigen and has been described to be present in normal, inflammatory, and neoplastic lymphatic capillary endothelium. Podoplanin is expressed selectively by dermal microvascular lymphatic endothelial cells but not by blood vascular endothelial cells. It is composed of heavily glycosylated extracellular domain and a short intracytoplasmic tail.
Immunogen
ラットポドプラニン由来合成ペプチドのアミノ酸111-129 (N末端システイン付加) のKLH結合体。この配列はマウスとは1アミノ酸残基異なっています。
Application
Anti-Podoplanin (HG-19) antibody produced in rabbit has been used in immunostaining, immunoblotting and immunofluorescence staining.
Biochem/physiol Actions
Podoplanin expression is regulated by the lymphatic-specific homeobox gene Prox-1. Podoplanin appears to play an important role in the maintenance of podocyte foot processes, and hence, glomerular permeability. It has a critical regulatory role in the formation of the lymphatic vasculature. Podoplanin does not seem to be upregulated in tumor angiogenesis. It is detectable in human angiosarcomas, lymphangiomas, and in Kaposi′s sarcomas.
Podoplanin is a marker of lymphatic endothelial cells. It may have a role in tumor cell invasion and migration.
Physical form
0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
P1995-200UL: + P1995-BULK: + P1995-VAR: + IXO11490:
jan
Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine
David Roulois
Oncotarget (2016)
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
Hong YK, et al.
Developmental Dynamics, 225(3), 351-357 (2002)
Changes in the rat subcutaneous connective tissue after saline and histamine injection in relation to fluid storage and excretion
Daitoku D, et al.
Archives of Histology and Cytology, 70(1), 29-41 (2007)
Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model
Ichiro Hirahara
BioMed Research International (2015)
Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fromter rats
D.H.T.Ijelaar
The American Journal of Physiology (2007)
関連コンテンツ
Instructions
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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