P248
モノクローナル抗PARP抗体 マウス宿主抗体
clone C-2-10, ascites fluid
別名:
モノクローナル抗ポリ[ADP-リボース]ポリメラーゼ抗体
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この商品について
Conjugate:
unconjugated
Clone:
C-2-10, monoclonal
Application:
ELISA
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
hamster, rat, mouse, primate
Citations:
30
Technique(s):
ELISA: suitable (Assay Dependent)
immunocytochemistry: suitable (Assay Dependent)
immunofluorescence: suitable (Assay Dependent)
immunohistochemistry: 1:10-1:100
western blot: 1:500
immunocytochemistry: suitable (Assay Dependent)
immunofluorescence: suitable (Assay Dependent)
immunohistochemistry: 1:10-1:100
western blot: 1:500
Uniprot accession no.:
製品名
モノクローナル抗PARP抗体 マウス宿主抗体, clone C-2-10, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
C-2-10, monoclonal
mol wt
antigen 116 kDa (PARP)
antigen 85 kDa (prICE/caspase-3 cleavage product)
species reactivity
hamster, rat, mouse, primate
should not react with
avian
technique(s)
ELISA: suitable (Assay Dependent)
immunocytochemistry: suitable (Assay Dependent)
immunofluorescence: suitable (Assay Dependent)
immunohistochemistry: 1:10-1:100
western blot: 1:500
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Parp1(11545), Parp2(11546)
rat ... Parp1(25591), Parp2(290027)
関連するカテゴリー
Biochem/physiol Actions
エピト-プは、PARPのDNA結合ドメインのアミノ酸216-375の間に認められます。抗体は、PARP(116 kDa)およびアポト-シス誘導によるprICE(proteinase resembling interleukin 1β-converting enzyme)およびカスパ-ゼ3(CPP32システインプロテア-ゼ)の切断産物(85 kDa)と反応します。
PARP1 poly(ADP-ribose) polymerase 1) and its enzymatic product PAR controls cellular processes like DNA repair, chromatin remodeling, transcription and cell death. PARP1 regulates transcription. PARP1 can induce or block homologous recombination (HR).
Poly (ADP-ribose) polymerase 1 (PARP1)/PARP participates in DNA repair. It facilitates homologous recombination. PARP controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system. PARP1 is also implicated in the maintenance of genomic stability.
Application
Monoclonal Anti-PARP (Cleaved-Asp214) antibody has been used in western blotting and immunohistochemical staining.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-PARP (mouse IgG1) is produced by immunizing mice with purified calf thymus poly (ADPribose) polymerase as the antigen. This antibody recognizes a 116kDa protein which corresponds to PARP and the 85kDa apoptosis induced cleavage product of prICE (proteinase resembling interleukin 1b-converting enzyme) and CPP32 (cysteine protease). It also recognizes PARP from mouse, rat, hamster and primate sources, but fails to detect avian PARP.
Poly (ADP-ribose) polymerase 1 (PARP1)/PARP is encoded by the gene mapped to human chromosome 1q42. It is a nuclear protein with molecular mass of 113kDa and is characterized with three functional domains. It belongs to the PARP superfamily.
Poly (ADP-ribose) polymerase 1 (PARP1)/PARP is encoded by the gene mapped to human chromosome 1q42. It is a nuclear protein with molecular mass of 113kDa and is characterized with three functional domains. It belongs to the PARP superfamily.
PARP1 poly(ADP-ribose) polymerase 1) is also termed as ARTD1. It is an abundant nuclear protein that belongs to the PARP family. This gene is located on human chromosome 1q42.
Immunogen
calf thymus PARP. The epitope is found between amino acids 216-375 in the DNA-binding domain of PARP.
Physical form
Solution in mouse ascites fluid containing 0.02% sodium azide.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Murai J, et al.
Cancer Research, 72(21), 5588-5599 (2012)
PARP-1 protein expression in glioblastoma multiforme
A. Galia, et al.
European Journal of Histochemistry, 56 (2012)
Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma
Martin-Perez D, et al.
The American Journal of Pathology (2010)
PARP-1 protein expression in glioblastoma multiforme
Galia A, et al.
European Journal of Histochemistry (2012)
Effects of single, double or triple combinations of octreotide, galanin and serotonin on a human pancreatic cancer cell line Article (PDF Available) ?in?Histology and histopathology 20(2):537-41 ? May
lineV. Tjomsland and M. El-Salhy
Histology and Histopathology (2005)
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