Application
タンパク質サンプルからDNAを除去したり、DNA結合タンパク質を精製したりする用途に使用します。レトロウイルス介在性の遺伝子移入を行う際に、ポリブレンの代替として使用することができます。
Biochem/physiol Actions
固体脂質ナノ粒子(SLN)の形態のプロタミンは、エステルクアト-1からなる同等のSLNと比べて、プラスミドDNAによるトランスフェクションをより効率的に促進し、細胞毒性が低くなりました。
硫酸プロタミンは低分子量の陽イオン性タンパク質で、DNAに結合し沈降させます。ヘパリンの抗凝固活性を中和します。リポタンパク質リパ-ゼを阻害します。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
L Willmitzer et al.
Biophysics of structure and mechanism, 6(2), 95-110 (1980-01-01)
The thermodynamics of protamine-DNA interation was investigated with clupeine Z from herring labeled at its amino terminus with fluorescein. The ionic strength dependence, the influence of protamine phosphorylation, of the native DNA conformation, using native and heat-denatured DNA, and of
Lisanne T Laagland et al.
JOR spine, 5(3), e1219-e1219 (2022-10-08)
Repopulating the degenerated intervertebral disc (IVD) with tissue-specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can
Chengming Liu et al.
BMC medicine, 20(1), 187-187 (2022-05-14)
Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines which influenced the responses and stimulated resistance to
L T Hansen et al.
International journal of food microbiology, 66(3), 149-161 (2001-06-29)
The antimicrobial effect of protamine (clupeine) on a range of gram-positive and gram-negative foodborne pathogens and spoilage bacteria, was evaluated using an agar dilution assay and a broth dilution assay with Alamar Blue as growth indicator. Protamine was tested alone
N Navaratnam et al.
European journal of biochemistry, 171(3), 623-629 (1988-02-01)
Galactosyltransferase was purified from Golgi membranes of lactating-rat mammary gland and studied with respect to its physical and enzymic (lactose synthetase) properties. The enzyme occurred in both monomeric (43-46 kDa) and apparently dimeric (90 kDa) forms. It was very unstable
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