P4506
ホスホジエステラーゼI Crotalus atrox (ニシダイヤガラガラヘビ)由来
Type IV, crude dried venom
別名:
5′-エキソヌクレアーゼ, オリゴヌクレアート5′-ヌクレオチドヒドロラーゼ
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この商品について
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-870-4
MDL number:
General description
Research area: Cell signalingPhosphodiesteraseI (PDEI) exists in three isoforms PDE1A,PDE1B, and PDE1C(2) that are locatedin cardiovascular, central nervous system, and other organs.
Application
Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) has been used to analyse its effect on intracellular calcium concentration of neutrophils. It has also been used in combination with other enzymes to determine the activity of phosphatase enzyme.
Phosphodiesterase I, product P4506 from western diamondback rattlesnake, is used in phosphodiesterase activation assays for calmodulin. It is added to hydrolyze AMP.
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. Phosphodiesterase I (PDEI) can hydrolyze 3′,5′-cyclicadenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP).It forms a complex with Ca2+/calmodulin (CaM) that leads to the activationof its catalytic activity.PDEIshows biotherapeutic effects for the treatment of cancer, diseases, neurocognitive,pulmonary, metabolic, heart, renal, neurological disorders, and endocrineabnormalities.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
P4506-25MG: + P4506-100MG: + P4506-500MG-PW: + P4506-VAR: + P4506-100MG-PW: + P4506-BULK: + P4506-500MG: + P4506-1G:
jan
Assessment of bioavailable organic phosphorus in tropical forest soils by organic acid extraction and phosphatase hydrolysis
Darch T, et al.
Geoderma, 284, 93-102 (2016)
Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function.
B Fuss et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(23), 9095-9103 (1997-12-31)
One of the more complex developmental processes occurring postnatally in the CNS is the formation of the myelin sheath by oligodendrocytes. To examine the molecular events that take place during myelination, we isolated oligodendrocyte-derived cDNA clones, one of which (p421.HB)
C J Brokaw et al.
The Journal of cell biology, 100(6), 1875-1883 (1985-06-01)
Sea urchin spermatozoa demembranated with Triton X-100 in the presence of EGTA, termed potentially asymmetric, generate asymmetric bending waves in reactivation solutions containing EGTA. After they are converted to the potentially symmetric condition by extraction with Triton and millimolar Ca++
Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein
Sultan MD, et al.
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(2), 177-183 (2016)
Omer Murik et al.
The Plant journal : for cell and molecular biology, 101(6), 1269-1286 (2019-10-29)
Mitochondria serve as major sites of ATP production and play key roles in many other metabolic processes that are critical to the cell. As relicts of an ancient bacterial endosymbiont, mitochondria contain their own hereditary material (i.e. mtDNA, or mitogenome)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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