P4743
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
別名:
Anti-Bcl-2 Binding Component 3, Anti-p53 Upregulated Modulator of Apoptosis
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
microarray
western blot
western blot
Species reactivity:
human
Citations:
13
Technique(s):
microarray: suitable
western blot: 2-4 μg/mL
western blot: 2-4 μg/mL
Uniprot accession no.:
製品名
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~23 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
microarray: suitable
western blot: 2-4 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BBC3(27113)
Application
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit has been used in western blotting and immunoprecipitation.
Biochem/physiol Actions
p53 upregulated modulator of apoptosis (PUMA) acts as a determinant of the levels of germ cells during ovarian development. It promotes apoptosis in various cellular stress insults. Deletion of the PUMA gene is observed in several kinds of human cancers.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
p53 upregulated modulator of apoptosis (PUMA) protein is a member of the B-cell lymphoma 2 (BCL2) family. It is a pro-apoptotic BCL-2 homology 3 (BH3)-only protein and has a small BH3 domain. The PUMA gene is mapped on the human chromosome at 19q13.32.
Immunogen
synthetic peptide corresponding to amino acids 2 to 16 of human PUMA-α.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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保管分類
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
P4743-BULK: + P4743-100UG-PW: + P4743-100UG: + P4743-VAR:
jan
Michelle Myers et al.
Reproduction (Cambridge, England), 148(2), 211-219 (2014-05-27)
The number of primordial follicles initially established within the ovary is influenced by the extent of germ cell death during foetal ovarian development, but the mechanisms that mediate this death have not been fully uncovered. In this study, we identified
Min Li et al.
Pharmaceuticals (Basel, Switzerland), 16(1) (2023-01-22)
Colorectal cancer is one of the most common malignancies, and the topoisomerase inhibitor irinotecan (CPT-11)-based chemotherapeutic regimen is currently the first-line treatment with impressive therapeutic efficacy. However, irinotecan has several clinically significant side effects, including diarrhea, which limit its clinical
C Li et al.
Cancer gene therapy, 23(9), 295-302 (2016-08-06)
Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck and is associated with a high rate of lymph node metastasis. The initial step in the metastasis and transition of tumors is epithelial-mesenchymal transition (EMT)-induced
P F Cartron et al.
Cell death & disease, 3, e421-e421 (2012-11-16)
Apoptosis has a crucial role in anti-cancer treatment. The proteins of the BCL-2 family are core members of the apoptotic program. Thus, we postulated that alterations in the expression of BCL-2 protein family, and in particular in that of the
Bibiana I Ferreira et al.
Haematologica, 93(5), 670-679 (2008-03-28)
Low-grade B-cell lymphomas are a very heterogeneous group of tumors, whose differential diagnosis is frequently compromised by the lack of specific cytogenetic or molecular features. Our objective was to search for genomic features that allow a better molecular identification of
関連コンテンツ
Datasheet
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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