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Merck

P5117

Anti-Peripherin antibody, Mouse monoclonal

clone 8G2, purified from hybridoma cell culture

別名:

Anti-NEF4, Anti-PRPH1

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01633973
Conjugate:
unconjugated
Clone:
8G2, monoclonal
Application:
immunohistochemistry
indirect ELISA
microarray
western blot
Species reactivity:
rat, bovine, pig, mouse, rabbit, feline, human
Citations:
18
Technique(s):
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract from rat PC12 cells
Uniprot accession no.:
P41219

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製品名

Anti-Peripherin antibody, Mouse monoclonal, clone 8G2, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

8G2, monoclonal

form

buffered aqueous solution

species reactivity

rat, bovine, pig, mouse, rabbit, feline, human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract from rat PC12 cells

isotype

IgG1

UniProt accession no.

P41219

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PRPH(5630)
mouse ... Prph(19132)
rat ... Prph(24688)

Application

Anti-Peripherin antibody, Mouse monoclonal has been used in:
  • immunohistochemistry
  • western blotting
  • enzyme linked immunosorbent assay (ELISA)
  • immunofluorescence staining

Biochem/physiol Actions

Peripherin is upregulated during pheochromocytoma PC12 cell differentiation. Later studies have detected peripherin also in certain central nervous system (CNS) neurons.
eripherin has been linked with axonal extension and regeneration of nerve fibers. It also has a role in neurite outgrowth propagation. Peripherin is a substrate of protein kinase B/Akt. Phosphorylation of this protein is induced after nerve injury.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Peripherin (mouse IgG1 isotype) is derived from the 8G2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the full-length recombinant rat peripherin. Peripherin was originally identified as a neuronal intermediate filament protein-(IF) is thought to be expressed only in the peripheral nervous system (PNS).
Peripherin is an intermediate filament protein. It is expressed in peripheral and enteric neurons. The gene encoding this protein is localized on rat chromosome 7.

Immunogen

full-length recombinant rat peripherin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

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保管分類

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

P5117-VAR: + P5117-200UL: + P5117-BULK:

jan

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試験成績書（COA）

Lot/Batch Number
0000512468
0000490628
0000490628
0000326151
0000363242

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以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Suppression of Extensive Neurofilament Phosphorylation Rescues alpha-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death
Lee WC, et al.
PLoS ONE, 7(8), e43883-e43883 (2012)
Rania Magadmi et al.
Frontiers in cellular neuroscience, 13, 262-262 (2019-07-06)
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external
Identification of peripherin as a Akt substrate in neurons.
Konishi H
The Journal of Biological Chemistry (2007)
Peripherin and ATF3 genes are differentially regulated in regenerating and non-regenerating primary sensory neurons.
Reid AJ
Brain Research (2010)
New insights into peripherin expression in cochlear neurons.
Lallemend F
Neuroscience (2007)
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関連コンテンツ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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