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P7136

ピラジンカルボキサミド

Name: ピラジンカルボキサミド
Brand: SIGMA

別名:

ピラジンアミド, ピラジン酸アミド

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この商品について

実験式（ヒル表記法）:

C₅H₅N₃O

CAS番号:

98-96-4

分子量:

123.11

UNSPSC Code:

41116107

NACRES:

NA.85

PubChem Substance ID:

24278648

EC Number:

202-717-6

Beilstein/REAXYS Number:

112306

MDL number:

MFCD00006132

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特性

form

powder

Quality Level

200

mp

189-191 °C (lit.)

antibiotic activity spectrum

mycobacteria

mode of action

cell membrane | interferes

SMILES string

NC(=O)c1cnccn1

InChI

1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)

InChI key

IPEHBUMCGVEMRF-UHFFFAOYSA-N

詳細

Application

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .

Biochem/physiol Actions

The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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試験成績書（COA）

Lot/Batch Number

0000413699

0000502702

0000502700

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Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity.

C Raynaud et al.

Microbiology (Reading, England), 145 ( Pt 6), 1359-1367 (1999-07-20)

Mycobacteria are known to acquire resistance to the antituberculous drug pyrazinamide (PZA) through mutations in the gene encoding pyrazinamidase (PZase), an enzyme that converts PZA into pyrazinoic acid, the presumed active form of PZA against bacteria. Additional mechanisms of resistance

Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination.

S A Tasduq et al.

Human & experimental toxicology, 25(3), 111-118 (2006-04-26)

Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was

Iron enhances the antituberculous activity of pyrazinamide.

Akos Somoskovi et al.

The Journal of antimicrobial chemotherapy, 53(2), 192-196 (2004-01-20)

Pyrazinamide is a paradoxical frontline tuberculosis drug characterized by high in vivo sterilizing activity but poor in vitro activity. This separation in pyrazinamide activity reflects differences between the in vivo tissue environment and in vitro culture conditions. The well-known acid