P8477
ピコタミド
別名:
4-メトキシ-N,N′-ビス(3-ピリジニルメチル)-1,3-ベンゼンジカルボキサミド
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この商品について
実験式（ヒル表記法）:
C21H20N4O3
CAS番号:
分子量:
376.41
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
251-245-7
MDL number:
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
SMILES string
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
assay
≥98%
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to light yellow
Quality Level
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
エイコサノイド受容体拮抗薬;トロンボキサンA 2拮抗薬 ;抗血小板薬。
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P A Modesti et al.
European journal of pharmacology, 169(1), 85-93 (1989-10-04)
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide
G Bettinetti et al.
Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)
A Giustina et al.
Diabetes, 47(3), 423-430 (1998-03-31)
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who
M Y Abeywardena et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)
Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with
G D'Andrea et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 27 Suppl 2, S96-S99 (2006-05-12)
Migraine with aura (MwA) sufferers, at times, need specific treatments. This is the case when the auras are frequent, prolonged and cause anxiety and distress. Abnormal release of glutamate, which may trigger auras, and abnormal platelet behaviour, which constitutes a
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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