S166
サクロフェン
solid
別名:
β-(アミノメチル)-4-クロロベンゼンエタンスルホン酸
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この商品について
実験式（ヒル表記法）:
C9H12ClNO3S
CAS番号:
分子量:
249.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
InChI key
JYLNVJYYQQXNEK-UHFFFAOYSA-N
SMILES string
NCC(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
form
solid
color
white
solubility
0.1 M NaOH: 20 mg/mL
Quality Level
Gene Information
human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)
Application
Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.
Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.
Biochem/physiol Actions
Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.
Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
S166-5MG: + S166-BULK: + S166-VAR:
jan
Eisuke Koya et al.
Neuropharmacology, 56 Suppl 1, 177-185 (2008-06-21)
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced cocaine seeking) in this
Molecular Mechanisms Underlying the Enhanced Analgesic Effect of Oxycodone Compared to Morphine in Chemotherapy-Induced Neuropathic Pain
Karine T
PLoS ONE (2014)
David P Archer et al.
Anesthesia and analgesia, 104(4), 840-846 (2007-03-23)
Synaptic plasticity is thought to provide a molecular mechanism for learning and memory. N-methyl-d-aspartate receptor-mediated plasticity requires that N-methyl-d-aspartate receptor activation coincides with postsynaptic depolarizing potentials (DPSP(A)'s). Pentobarbital, in high concentrations, enhances DPSP(A)'s, but high concentrations suppress synaptic plasticity, probably
N Bowery
Trends in pharmacological sciences, 10(10), 401-407 (1989-10-01)
Much progress has been made in GABAB receptor pharmacology since the discovery of this receptor in 1980. Selective agonists and antagonists have been developed and a functional role for the receptor as a mediator of slow inhibitory postsynaptic potentials in
Minoru Miyazato et al.
The Journal of urology, 179(3), 1178-1183 (2008-01-22)
We investigated the effects of intrathecal application of gamma-aminobutyric acid A and B receptor agonists on detrusor overactivity in spinal cord injured rats. Adult female Sprague-Dawley rats were used. At 4 weeks after Th9-10 spinal cord transection awake cystometry and
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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