S5069

抗スーパーオキシドジスムターゼ (MnSOD) (DD-17) ウサギ宿主抗体

Name: 抗スーパーオキシドジスムターゼ (MnSOD) (DD-17) ウサギ宿主抗体
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

別名:

抗IPO-B抗体, 抗MNSOD抗体, 抗Mn-SOD抗体, 抗SOD2抗体, 抗インドフェノールオキシダーゼB抗体, 抗スーパーオキシドジスムターゼ2抗体, 抗マンガンスーパーオキシドジスムターゼ2抗体, 抗マンガン依存性SOD抗体, 抗ミトコンドリアSOD抗体

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この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD06798545

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC (p), WB

Citations:

主要文書

すべての文書を表示

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~24 kDa

species reactivity

rat, human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using biotin/ExtraAvidin^®-peroxidase staining of human heart sections, indirect immunofluorescence: 10-20 μg/mL using methanol-acetone-fixed rat NRK cells, western blot: 1-2 μg/mL using human HeLa mitochondria extract and a chemiluminescent detection reagent, western blot: 2-4 μg/mL using whole extract of rat brain and a chemiluminescent detection reagent

UniProt accession no.

P04179

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... SOD2(6648)
rat ... Sod2(24787)

General description

Superoxide Dismutase (SOD) is a metalloprotein enzyme. It is widely distributed in the animal and plant kingdoms. The three common mammalian endogenous isozymes are the homodimeric copper-zinc SOD (Cu,ZnSOD, SOD1) found primarily in the cytosol, the homotetrameric glycosylated copper-zinc SOD, extracellular SOD (EC-SOD, SOD3), and the homotetrameric mitochondrial manganese SOD (MnSOD, SOD2). All three are nuclear-encoded. MnSOD is composed of four subunits, each containing one Mn²⁺.

Immunogen

ヒトス-パ-オキシドジスムタ-ゼ(MnSOD)のアミノ酸183~199(N末端システイン付加)に相当する合成ペプチドのKLH結合体。相当する配列は多くの真核生物で保存されています。

Application

The antibody may be detected by various immunochemical techniques including immunoblotting, co-immunoprecipitation assay (co-IP), immunoprecipitation, indirect immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

Superoxide Dismutase (SOD) catalyzes the dismutation of the cytotoxic superoxide radical (O² -) to molecular oxygen and hydrogen peroxide. Manganese SOD (MnSOD) has been proposed to function as a tumor suppressor by modulating the activity of redox-sensitive transcription factors and specific signal mediators. MnSOD is involved in detoxification.

Physical form

PBS溶液(pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

S5069-BULK: + S5069-VAR: + IXO11795: + S5069-200UL:

jan

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試験成績書（COA）

Lot/Batch Number

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特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt

Lai Y, et al.

International Journal of Molecular Medicine, 37(2), 369-377 (2016)

LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Wen-Su Wei et al.

Redox biology, 48, 102201-102201 (2021-12-06)

Reactive oxygen species (ROS) which are continuously generated mainly by mitochondria, have been proved to play an important role in the stress signaling of cancer cells. Moreover, pentatricopeptide repeat (PPR) proteins have been suggested to take part in mitochondrial metabolism.

Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt.

Yuanhui Lai et al.

International journal of molecular medicine, 37(2), 369-377 (2015-12-29)

The sensitization of breast cancer stem cells (BrCSCs) to the inhibitive effects of radiotherapy through adjuvant therapy which targets oncogenic pathways represents a prospective strategy for improving the effect of radiation in patients with triple-negative breast cancer (TNBC). Mammalian target

Tetramerization reinforces the dimer interface of MnSOD

Sheng Y, et al.

PLoS ONE, 8(5), e62446-e62446 (2013)

SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma

Chang B, et al.

Scientific Reports, 6 (2016)

抗スーパーオキシドジスムターゼ (MnSOD) (DD-17) ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

サイズを選択してください

この商品について

主要文書

特性

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

enhanced validation

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

関連するカテゴリー

詳細

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Legal Information

Disclaimer

安全性情報

保管分類

wgk

flash_point_f

flash_point_c

適用法令

S5069-BULK: + S5069-VAR: + IXO11795: + S5069-200UL:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

プロトコルと関連資料

関連コンテンツ

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