S5567
SP600125
≥98% (HPLC), powder or solid, JNK inhibitor
別名:
1,9-ピラゾロアントロン, アントラピラゾロン
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この商品について
実験式（ヒル表記法）:
C14H8N2O
CAS番号:
分子量:
220.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-955-6
MDL number:
Assay:
≥98% (HPLC)
Quality level:
製品名
SP600125, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
color
yellow
solubility
DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1c2ccccc2-c3n[nH]c4cccc1c34
InChI
1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChI key
ACPOUJIDANTYHO-UHFFFAOYSA-N
Gene Information
human ... JUN(3725), MAPK10(5602), MAPK9(5601)
Application
筋形成の刺激を試験するためC2C12筋芽細胞をSP600125で治療しました。11オキシステロール誘導性ネクローシスに対する影響を試験するためHepG2細胞の治療にSP600125を用いました。12
Biochem/physiol Actions
SP600125は、ATPと競争してc-Junのリン酸化を阻害するJNKのアントラピラゾロン阻害薬です。SP600125は、COX-2、IL-2 IFN-γおよびTNF-αなどの炎症性遺伝子の活性化を阻害します。8,9SP600125は脳虚血後のJNKの活性化を阻害し、虚血性脳卒中の治療に有効である可能性があります。10
c-Jun N末端キナ-ゼ(JNK)選択的な新規インヒビタ-です。
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
資料
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Adrian Vallejo et al.
Nature communications, 8, 14294-14294 (2017-02-22)
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report
Cheng Yin et al.
Cell transplantation, 28(6), 691-703 (2018-10-24)
Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little
Chenglu Peng et al.
Journal of agricultural and food chemistry, 67(32), 9009-9021 (2019-07-19)
Soybean allergy is a serious health risk to humans and animals; β-conglycinin is the primary antigenic protein in soybean. Intestinal porcine epithelial (IPEC-J2) cells were used as an in vitro physiological model of the intestinal epithelium to study the effects